The aim of the present study was to prepare and evaluate the transdermal patch of drug using different polymers such as hydrophobic, combination of hydrophobic: hydrophilic, and hydrophilic. Losartan potassium (hydrophilic) is the antihypertensive drug used for lowering increased blood pressure. Transdermal patches of losartan potassium were prepared using different ratios of polymers by the solvent casting technique. The prepared patches were evaluated for their flexibility, thickness, smoothness, moisture content, hardness, and tensile strength. The in vitro permeation study was carried out using a diffusion cell. The blood lowering response of all formulations was studied using hypertension-induced rats. The formulation containing hydrophobic polymers showed a satisfactory drug release pattern compared to the combination of hydrophobic: hydrophilic polymers and the hydrophilic polymers. Hence, the present study reveals that formulation of hydrophilic drug (losartan potassium) withhydrophobic polymers exhibit good release properties as compared to that of hydrophilic polymers and combination of both hydrophobic and hydrophilic polymers.
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