&lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P

Baviskar, Dheeraj T.; Biranwar, Yogeshkumar A.; Bare, Kapil R.; Parik, Venkatesh B.; Sapate, Mangesh K.; Jain, Dinesh Kumar

doi:10.4314/tjpr.v12i4.7

Cited by 12 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diffusion study of formulations was measured in the triplicate and average value ± standard deviation was calculated. 24…”

Section: In-vitro Drug Diffusion Studymentioning

confidence: 99%

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Borse¹,

Gangude²,

Deore³

2019

IJPER

View full text Add to dashboard Cite

Purpose: To formulate novel topical antibacterial gel containing Doxycycline Hyclate, Tea tree oil and Neem oil to evaluate their antibacterial activity. Methods: Formulation excipients were selected using Drug-excipients compatibility study. Prepared gel was subjected to various evaluation parameters like pH, viscosity, spreadability, homogeneity, drug content uniformity, in-vitro drug diffusion and antibacterial activity. Results: Prepared topical gel of doxycycline Hyclate was shown pH range 5.3±0.010 to 6.7±0.015, viscosity range 386±28.70 to 680±50.40 cp, spreadability range 18.14±0.98 to 28.13±2.18 g.cm/s and homogeneous. Prepared gel was shown uniformity in drug content which ranges from 94.41±0.61 to 97.44±0.69%, zone of inhibition ranges 13.66±1.69 to 32.00±1.63 mm for Staphylococcus aureus, 04.00±1.63 to 12.33±0.94 mm for Pseudomonas aeruginosa and 11.66±0.94 to 33.33±1.24 mm for Propionibacterium acne. Prepared gel formulations were shown the negligible amount of drug diffusion, not more than 3.22±0.04% was shown the non-fickian type of diffusion through the egg membrane. Conclusion: Formulation F8 was shown better antibacterial activity as compared to its other formulations. As the concentration of neem oil and tea tree oil was increased from 0.5 to 3% and 0.5 to 2% respectively in the gel, antibacterial activity was synergistically improved against Staphylococcus aureous, Pseudomonas aeruginosa and Propionibacterium acne. The prepared gel formulation was found useful for topical application due to its negligible diffusion, good spreadability, neutral pH, low viscosity and no irritation on human skin.

show abstract

“…Diffusion study of formulations was measured in the triplicate and average value ± standard deviation was calculated. 24…”

Section: In-vitro Drug Diffusion Studymentioning

confidence: 99%

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Borse¹,

Gangude²,

Deore³

2019

IJPER

View full text Add to dashboard Cite

show abstract

“…All developed gels showed good homogeneity with the absence of lumps. The developed preparations were much clear and transparent [13]. The results are shown in Table 2.…”

Section: Homogeneitymentioning

confidence: 88%

Formulation and Evaluation of Gel Loaded With Microspheres of Apremilast for Transdermal Delivery System

Priyanka¹,

Neeraja²,

Mangilal³

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The main objective of the present research work was to formulate and evaluate gel loaded with microspheres of apremilast to increase bioavailability and to reduce the dosing frequency and to improve patient compliance. Methods: Gel loaded with microspheres of apremilast was prepared by solvent evaporation method by taking different ratios of polymers. Ethyl cellulose as a polymer, dichloromethane solvent is used as drug solubility, polyvinyl alcohol as a surfactant, and sodium alginate is used as gelling agent. Prepared gel loaded with microspheres was evaluated for drug interactions by Fourier transform infrared (FTIR), differential scanning calorimetry studies, and surface morphology by scanning electron microscopy (SEM), to select effective one among all formulations. The prepared formulations (F1–F6) were evaluated for pre-formulation studies, spreadability, viscosity, pH measurement, gel strength, homogeneity, drug content, in vitro diffusion studies, drug kinetics, and finally for stability studies. Results: Differential scanning calorimeter studies confirmed that there is no drug interaction between drug and excipients. FTIR spectroscopy studies confirmed that there is compatibility between drug and excipients. Regular and spherical shape particles with smooth surface were observed in the SEM photographs. The optimized gel loaded with microspheres of F4 formulation (drug: polymer in 1:4 ratio) is more effective compared to all formulations. The prepared gel showed acceptable physical properties such as spreadability (5.86±0.54 g.cm/s), viscosity (568 cps), pH (6.33±0.55), gel strength (38 s) and drug content (90.00±0.71%). In vitro diffusion studies have shown 80.1±1.92% drug release in 10 h. Drug kinetics follows zero order kinetics and n value was found to be 0.721. Stability studies were done for 3 months. Conclusion: All the results show that the gel loaded with microspheres of apremilast can be effectively used for the treatment of psoriasis and psoriatic arthritis.

show abstract

“…Selanjutnya campuran larutan pertama ditambahkan ke dalam basis gel yang telah terbentuk kemudian ditambahkan akuades hingga mencapai berat gel yang diinginkan. 10…”

Section: Proses Pembuatan Gelunclassified

“…Persen karboksil pada pati teroksidasi ini sesuai dengan spesifikasi rentang jumlah karboksil dalam pati teroksidasi yaitu ≥0,3 %. 10 Pada pati terasetilasi-oksidasi dilakukan evaluasi modifikasi dengan menghitung persen asetil, DS (Degree of Substitution) dan persen karboksil. Pada evaluasi persen karboksil didapatkan persen karboksil sebesar 0,765 ± 0,005%.…”

Section: Diskusiunclassified

Pengaruh Penggunaan Pati Kentang (Solanum tuberosum) Termodifikasi Asetilasi-Oksidasi Sebagai Gelling Agent Terhadap Stabilitas Gel Natrium Diklofenak

Danimayostu

2017

PJI

View full text Add to dashboard Cite

Gel merupakan sistem semipadat yang dibuat dari partikel anorganik yang kecil atau molekul organik yang besar, terpenetrasi oleh suatu cairan. Gelling agent merupakan komponen polimer yang mempunyai berat molekul tinggi dan merupakan gabungan dari beberapa molekul dan lilitan dari polimer yang akan memberikan sifat kental pada gel. Pati kentang memiliki nilai swelling power dan viskositas tinggi dibandingkan dengan pati lainnya, yang keduanya mempunyai peran penting terhadap fungsi pati sebagai gelling agent. Modifikasi asetilasi-oksidasi mengakibatkan terjadinya peningkatan viskositas dan kejernihan pada gel yang dihasilkan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian pati kentang (Solanum tuberosum) termodifikasi asetilasi-oksidasi sebagai Gelling agent pada stabilitas gel yang mengandung natrium diklofenak. Studi eksperimental menggunakan metode uji stabilitas real time dan freeze thaw dilakukan terhadap gel natrium diklofenak. Sampel dibagi menjadi empat kelompok yaitu kelompok gel "pati terasetilasi-oksidasi", kelompok gel "pati terasetilasi", kelompok gel "pati teroksidasi" dan kelompok gel "pati alami". Variabel yang diukur pada penelitian ini adalah stabilitas fisik dan kimia dari gel natrium diklofenak yang dihasilkan. Hasil penelitian menunjukkan bahwa stabilitas fisik antara gel pati terasetilasi-oksidasi dengan gel pati terasetilasi, gel pati teroksidasi dan gel pati alami memliki nilai yang berbeda bermakna (Oneway Anova, p<0,05). Tidak terjadinya perubahan stabilitas fisik dan kimia pada semua kelompok gel setelah uji stabilitas real time dan freeze-thaw pada semua evaluasi sediaan gel (Uji T Berpasangan, p>0,05). Namun demikian, terjadi perubahan pada daya sebar gel pada semua kelompok setelah uji stabilitas freeze-thaw (Uji Wilcoxon, p<0,05). Kesimpulan dari penelitian ini adalah pati kentang (Solanum tuberosum) modifikasi asetilasi-oksidasi dapat mempertahankan stabilitas gel natrium diklofenak berdasarkan karakteristik gel yaitu organoleptik, viskositas, pH, daya sebar dan kadar natrium diklofenak..

show abstract

<i>In Vitro</i> and <i>In Vivo</i> Evaluation of Diclofenac Sodium Gel Prepared with Cellulose Ether and Carbopol 934P

Abstract: Purpose: To develop diclofenac sodium gel using high molecular weight hydroxypropyl methylcellulose (HPMC)

Cited by 12 publications

References 10 publications

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Formulation and Evaluation of Gel Loaded With Microspheres of Apremilast for Transdermal Delivery System

Pengaruh Penggunaan Pati Kentang (Solanum tuberosum) Termodifikasi Asetilasi-Oksidasi Sebagai Gelling Agent Terhadap Stabilitas Gel Natrium Diklofenak

Contact Info

Product

Resources

About