Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems

Abstract

Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side effects. Methods: The present investigation preparation and screening of rate controlling membranes using Eudragit release liners of RS 100, hydroxyl propyl methyl cellulose K4M (HPMC K4M) and ethyl cellulose by plate casting method and their physicochemical characterization. The prepared release liners were subjected for preformualtion studies (thickness, weight variation, moisture uptake, folding endurance and moisture loss). Tamoxifen citrate is an ideal molecule for the transdermal reservoir for the preparation of gel dosage form due its dosage regimen. Results: The main investigation, topical gel TC was prepared using HPMC K4M and Carbopol 934 as gelling agents in different proportions with Dimethyl Sulfoxide (DMSO) as a penetration enhancer. TC gels were subjected for the physicochemical parameters such as pH, viscosity, spreadability. Conclusion: The TC gel diffusion was conducted by using rate controlling membranes (release liner). The TC gel skin permeation was investigated by using excised rat skin as a barrier.

Formulation-by-Design of Efinaconazole Spanlastic Nanovesicles for Transungual Delivery Using Statistical Risk Management and Multivariate Analytical Techniques

“…For scanning electron microscopy (SEM) in cryo mode, the spanlastic formulation, blank carbopol gel, and efinaconazole-loaded spanlastic dispersed in carbopol gel were frozen in liquid nitrogen, followed by coating with platinum. Samples were viewed in FEG-SEM (Quorum Technologies, Laughton, East Sussex, UK) [ 28 , 29 ].…”

Gel Formulations for Topical Treatment of Skin Cancer: A Review

“…The polymer provides a wide range of viscosity grades depending on the substitution degree and ratios [94]. The systematic search retrieved four articles considering HPMC as a gelling agent in physical hydrogels [95][96][97][98]. Two of them investigated the incorporation of cyclodextrin complexes with APIs into a semisolid gel.…”

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“…Finally, the findings of this study suggest that by using a suitable adhesive layer and backing membrane, DB: Eudragit RL100 (60:40) transdermal patches could be used for therapeutic purposes. (Mundada and Avari 2011) 18 analyzed that the transdermal delivery of hormonal therapy had several advantages over the oral route, including the incidence of side effects.…”

“…At the end, rate-controlling membranes were also used to perform Tamoxifen citrate gel diffusion (release liner). Finally, the skin permeation of Tamoxifen Citrate gel was studied using excised rat skin as a barrier 18 Manish Kumar et al, (2018). Their research aimed to use a solvent evaporation method to create a transdermal drug delivery system containing atenolol with various ratios of hydrophilic and hydrophobic polymeric combinations, as well as to investigate the effect of polymer hydrophilicity and hydrophobicity on the physicochemical and drug release characteristics of transdermal patches.…”