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We describe the photophysical properties of Seta-633, a commercially available near-infrared (NIR) dye, and its use as a fluorescent label to study the interaction between low-molecular-weight analytes and proteins using fluorescence lifetime as the readout parameter. In a model assay, we demonstrate that a biotinylated Seta-633 tracer binds to antibiotin with high specificity. Importantly, the lifetime of Seta-633-biotin increases about 1.8-fold upon binding to a specific antibody (antibiotin, MW = 160 kDa), while the titration with bovine serum albumin (BSA) or nonspecific antibody does not result in a noticeable change in lifetime. This behavior is contrary to that of fluorescent tracers like Cy5 or Alexa 647, which typically exhibit much smaller lifetime changes upon binding to antibodies.

Modern processes of reforming the agroindustrial complex of Ukraine, a large part of which belongs to the agrarian sector, under the globalization of world economic processes in the agricultural market require that domestic agroindustrial enterprises improve and rationally manage innovative activities (IА). The effective solution of problems that arise in this context in the rapidly changing economic and social and political environment requires that analytical methods in the management of the enterprises of the agroindustrial complex (AIC) be used on the basis of the tools of economic and mathematical modelling, taking into account characteristics of agrarian production. The main approaches to modelling systems related to IА management are either descriptive or insufficiently formalized, and suggest virtual experimenting with IA management, avoiding the possibility of assessing the impact and consequences of different management options in the long view, minimizing IA risks when making managerial decisions. The subject matter of the article is the tools of economic and mathematical simulation of the development of innovative activities of the domestic agroindustrial complex. The goal is to develop tools for modelling innovative activities of enterprises of the agroindustrial complex of Ukraine in the form of analytical dependencies of impact factors. The objective is to research the dynamics of innovative activities of enterprises of the agroindustrial complex of Ukraine in terms of its components under the globalization of world economic processes in the market of agricultural products. General scientific methods are used, such as system analysis -to determine the peculiarities of development of IА of agroindustrial production in Ukraine, factor analysis -to formalize the cause-and-effect relationships of the investigated factors of AIC enterprises impact on IA. The following results were obtained: on the basis of the analysis of the dynamics of changes in the major indices of domestic agricultural production, the problem aspects were identified and the components of IA of agricultural production were determined, latent factors with prolonged impact on the level of innovative activities of agricultural enterprises of Ukraine were calculated. Conclusions: the calculated latent factors of the impact of AIC enterprises on IА can be efficiently used in foreign economic activities as recommendations for determining the IА strategy of Ukraine in the world agricultural market.

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