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Objectives:Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models.Materials and Methods:Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50 mg/kg and 100 mg/kg.Results:The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100 mg/kg (i.p.) and was comparable to that of standard analgin (150 mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50 mg/kg and 100 mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5 mg/kg).Conclusion:Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

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Thiadiazole derivatives R 0300Studies on Synthesis and Pharmacological Activities of 3,6-Disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and Their Dihydro Analogues. -Several triazolothiadiazoles (IV) (27 examples) and related dihydro derivatives (VI) (12 examples) are synthesized by condensation of mercaptotriazoles (II) with carboxylic acids or aldehydes, respectively. Some of the products show significant antimicrobial [e.g. (IVd)] or good antiinflammatory and analgesic activities [e.g. (IVf)]. -(MATHEW*, V.; KESHAVAYYA, J.; VAIDYA, V. P.; GILES, D.; Eur. J. Med. Chem. 42 (2007) 6, 823-840; Pharm. Chem., Acharya & B. M. Reddy Coll. Pharm., Bangalore 560 090, India; Eng.) -A. Forchert 42-124

Oxadiazole derivatives R 0290Synthesis, Antimicrobial and Antiinflammatory Activities of 1,3,4-Oxadiazoles Linked to Naphtho[2,1-b]furan. -A variety of novel title oxadiazole derivatives are synthesized starting from hydrazides (I) and evaluated for their biological activities. Derivatives (IVb) and (IVc) exhibit promising antimicrobial activities. Compound (IVc) exhibits also a potent antiinflammatory activity. -(RAVINDRA, K. C.; VAGDEVI*, H. M.; VAIDYA, V. P.; PADMASHALI, B.; Indian J.