Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: A novel class of potential antibacterial and antitubercular agents

Joshi, S. D.; Vagdevi, H. M.; Vaidya, V. P.; Gadaginamath, G. S.

doi:10.1016/j.ejmech.2007.11.016

Cited by 190 publications

(70 citation statements)

References 9 publications

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“…sulphuric acid. 15 The alkylation of 1,3,4-thiadiazoles (4) with substituted phenycyl bromide, in presence of dimethyl sulfoxide afford a new series of 1-(2,5-disubstitutedphenyl)-2-(5-((substitutedphenylamino)methyl)-1,3,4-thiadiazol-2-ylthio)ethanone (5a-f).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Evaluation and Molecular Docking Study of Some New Acetic Acid Derivatives.

Kerur¹,

Alagawadi²,

Zhu³

et al. 2016

IJPER

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In the present study synthesis and antimicrobial activity of some new 2-[(2,5-disubstitutedanilino)phenyl]acetic acid derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1 H NMR, 13 C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Evaluation and Molecular Docking Study of Some New Acetic Acid Derivatives.

Kerur¹,

Alagawadi²,

Zhu³

et al. 2016

IJPER

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“…The triazole (77) was condensed with 70 in the presence of catalytic amount of H 2 SO 4 in refluxing ethanol to afford 78. Synthesized compound 78 was evaluated (Shiradkar et al 2007;Joshi et al 2008) for its preliminary cytotoxicity and antitubercular activity against M.tb. H 37 Rv strain by broth dilution assay method and showed a promising activity (MIC = 4 µg/mL).…”

Section: Scheme 11 Synthesis Of Toluidine Derivativesmentioning

confidence: 99%

Cinnamic Derivatives in Tuberculosis

De¹,

Veau²,

Bedos‐Belval³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

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“…The pyrrole containing other heterocyclic compounds has been reported previously for biological studies [9]. Oxadiazole linked with pyrrole derivatives are display a broad spectrum of biological activity such as antimicrobial activity [10], antitubercular agents [11]. Triazole linked with pyrrole derivatives have importance of biological and pharmaceutical importance activity such as anti-inflammation [12,13], antitumor [14] and antimicrobial [15][16][17].…”

Section: Introductionmentioning

confidence: 99%