Synthesis, Antimicrobial and Antiinflammatory Activities of 1,3,4‐Oxadiazoles Linked to Naphtho[2,1‐b]furan.

Abstract

Oxadiazole derivatives R 0290Synthesis, Antimicrobial and Antiinflammatory Activities of 1,3,4-Oxadiazoles Linked to Naphtho[2,1-b]furan. -A variety of novel title oxadiazole derivatives are synthesized starting from hydrazides (I) and evaluated for their biological activities. Derivatives (IVb) and (IVc) exhibit promising antimicrobial activities. Compound (IVc) exhibits also a potent antiinflammatory activity. -(RAVINDRA, K. C.; VAGDEVI*, H. M.; VAIDYA, V. P.; PADMASHALI, B.; Indian J.

Mannich bases in medicinal chemistry and drug design

“…Phenylpiperazine-containing Mannich base 139j was generally more potent that candidate 139j derived from ethyl isonipecotate, but both had moderate antibacterial activity compared to reference drug ampicillin [176]. Three out of eight synthesized Mannich bases 139k were screened for antibacterial activity, but their growth inhibition was only weak to moderate (inhibition zones of 12e26 mm) compared to that of reference drug chloramphenicol (inhibition zones of 37e44 mm) [200]. None of the 21 synthesized Mannich bases 139l presented any antibacterial activity at the maximum concentration tested (250 mg/mL) [98].…”

S-Alkylated/aralkylated 2-(1H-indol-3-yl-methyl)-1,3,4- oxadiazole-5-thiol derivatives. 1. Synthesis and characterization

“…The synthesis and analysis of chemical and biological behaviors of 2, 5-disubstituted-1,3,4-oxadiazole-2-thiol derivatives have gained substantive importance in the past few decades for biological, medical and agricultural reasons [1][2][3][4][5]. Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acyl hydrazides and acids can be done by acid activation with CDI, followed by coupling with the required acyl hydrazide and dehydration in the same pot with CBr 4 and Ph 3 P [6].…”

Synthesis and Pharmacological Evaluation of a Novel Series of 2‐((2‐Aryl thiazol‐4‐yl)methyl)‐5‐(alkyl/alkylnitrile thio)‐1,3,4‐oxadiazole Derivatives as Possible Antifungal Agents

“…The presence of oxadiazole nucleus in diverse types of compounds proves its importance in the field of medicinal chemistry. Oxadiazole possesses a wide spectrum of biological activities such as antimicrobial , anti‐tubercular , anti‐inflammatory , antiviral , tyrosianse inhibitor activity , EGFR PTK inhibitor , anticancer , anticonvulsant , and protoporphyrinogen oxidase inhibitor activities.…”