Synthesis and Pharmacological Evaluation of a Novel Series of 2‐((2‐Aryl thiazol‐4‐yl)methyl)‐5‐(alkyl/alkylnitrile thio)‐1,3,4‐oxadiazole Derivatives as Possible Antifungal Agents

Abstract

in Wiley Online Library (wileyonlinelibrary.com). R R 1 a-c 4 a-l; 5a-cIn the present investigation, a novel series of 2-[(2-arylthiazol-4-yl)methyl]-5-(alkyl/alkylnitrile thio)-1,3,4-oxadiazole derivatives were synthesized by cyclo-condensation of 2-(2-substituted thiazol-4-yl)aceto hydrazide with carbon disulfide followed by S-alkylation with alkyl halide in dry acetone. All the newly synthesized compounds were characterized by spectral (IR, 1 H NMR, 13 C NMR, mass, and elemental analysis) methods. The title compounds were screened for in vitro antifungal activity and most of the synthesized compounds show moderate to good antifungal activity.

New 1,2,4‐Triazole Scaffolds as Anticancer Agents: Synthesis, Biological Evaluation and Docking Studies

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“…Medicinal chemistry was developed from an empirical organic synthesis of novel entities by modification of structure and identification of their biological activity. Furthermore, heterocyclic compounds are well known pharmaceutically active products, and the development of simple and efficient methods for the synthesis of compounds incorporating heterocyclic rings has given a new dimension to drug discovery [9] …”

Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties

“…Heterocyclic compounds are well-known for their pharmaceutical importance, and the research for simple and efficient methods of synthesis of compounds incorporating heterocyclic rings has brought a new dimension to drug development [ 1 ]. In past decades heterocyclic scaffolds such as the 1,2,4-triazole, 1,3,4-oxadiazole and 1,3,4-thiadiazole rings and their derivatives were intensively investigated by researchers because of their biological activity.…”

Design, Synthesis, Characterization, and Antimicrobial Screening of Novel Indazole Bearing Oxadiazole Derivatives

“…Some 1 H ‐indazole‐4,7‐quinones possess anthelmintic and diuretic activity . A series of indazole derivatives exhibit herbicide activity, behave as growth inhibitors , or are used as bactericides and fungicides in polymer‐based paints . Guanidino‐1 H ‐indazoles are used as sweeteners .…”