Antioxidant, cytotoxic and genotoxic evaluation of alcoholic extract of Polyalthia cerasoides (Roxb.) Bedd.

6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone Induces Caspase-8- and -9-mediated Apoptosis in Human Cancer Cells

“…This present study confirmed the previous studies of the inhibitory effects of the active compound(s) or extract from Polyalthia cerasoides on the human cancer cell proliferation such as CACO-2 (Ravikumar et al, 2010), L929 (Ravikumar et al, 2008), A549, GLC4 and GLC4/ Adr (Pumsalid et al, 2010). 6,8-Dihydroxy-7-methoxy-1-…”

“…at a dose of 100 μg/kg significantly prevents the increase in serum transaminases, serum alkaline phosphatase, liver and brain lipid peroxidation and decreases total protein content in liver and brain following carbontetrachloride-induced hepatotoxicity in albino rats (Padma et al, 1999). The alcohol extract of Polyalthia cerasoides contains significant reactive oxygen species (ROS) scavenging activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, superoxide anion scavenging, and reducing power assays; antiproliferative effect against mouse fibroblast L929 cell line; and a high level of total phenolic content in vitro (Ravikumar et al, 2008). Two phytosterols (alpha-spinasterol and spinasterol) and a clerodane di-terpenoid are isolated from Polyalthia cerasoides seeds and contain antiproliferative and apoptotic induction effect in CACO-2 cell line (Ravikumar et al, 2010).…”

Antiproliferative Activity of Marrubium persicum Extract in the MCF-7 Human Breast Cancer Cell Line

“…Owing to the fact that anticancer activity of plants has been verified to be connected with a variety of phytochemicals, such as polyphenols, flavonoids and catechins (Uddin et al, 2009), many researchers had also confirmed higher phenolic content of plant materials increases the antioxidant activity of the plant since there is a linear correlation between phenolic contents and antioxidant activity (Rietjens et al, 2005;Ravikumar et al, 2008;Rahman et al, 2011). Although plant phenolics are good source of antioxidants, they differ in their abilities to quench various free radicals, so as verifying the exact role of these phytochemicals in certain kind of an oxidative stress related diseases is of substantial importance.…”

Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats

“…Polyalthia cerasoides (Roxb.) Bedd have potential antioxidant, cytotoxic and genotoxic activities (Ravikumar et al, 2008) and antiproliferative, apoptotic and antimutagenic activities (Ravikumar et al, 2010). The present work is an acute toxicological study of Polyalthia longifolia var.…”