Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats

Chanda, Sumitra; Dave, Rajeshkumar; Kaneria, Mital J.; Shukla, VJ

doi:10.3109/13880209.2012.682117

Cited by 28 publications

(18 citation statements)

References 39 publications

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“…Although there are a few reports about cytotoxicity of diterpenes 2 and 3 against cancer cell lines, including human lung carcinoma A549 , human breast carcinoma MCF-7 , human colon adenocarcinoma HT-29 cells 15,23 , these reports did not indicate induction of apoptosis. In addition, the methanol extract of P. longifolia leaves and isolated 16a-hydroxy-cleroda-3,13 14 Z-dien-15,16-olide 3 have been reported to be non-toxic and safe in in vivo models 16,24 . Thus, P. longifolia seems to be a chemopreventive and orally active medicinal plant.…”

Section: Resultsmentioning

confidence: 99%

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

et al. 2013

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Section: Resultsmentioning

confidence: 99%

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

et al. 2013

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“…Briefly, the weight of the daily feed supply and the left-over feed by the following day was recorded and the difference was taken as the daily feed intake. The average of the feed intake was computed for every three days of the experimental period [39].…”

Section: Determination Of Body Weight and Feed Intakementioning

confidence: 99%

An Investigation of The Trivedi Effect®-Energy of Consciousness Healing Treatment to Modulate the Immunomodulatory Effect of Herbomineral Formulation in Male Sprague Dawley Rats

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

AJBLS

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Abstract:Herbomineral formulations are used world-wide for various therapeutic purposes. More than 80% of the world population relies on natural herbal and mineral remedies as medicines for their health care. A new proprietary herbomineral formulation was created, consisting of the herbal root extract ashwagandha and minerals (zinc, magnesium, and selenium). The aim of the study was to evaluate the immunomodulatory potential of the Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on the herbomineral formulation in male Sprague Dawley rats. The test formulation was divided into two parts. One part was denoted as the control without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely from eighteen renowned Biofield Energy Healers. The immunomodulatory effect of the Biofield Energy Treated and the untreated test formulations were studied to determine any alterations in the animal humoral immune response, paw volume, hematological study, serum biochemistry parameters, animal weight parameters, feed intake and histopathology analysis. Humoral immune response data of the reference standard (levamisole) showed a significant increase in secondary antibody titre value (p≤0.05), while the Biofield Treated test formulation group (G3) exhibited a significant increase in the secondary antibody titre by 115.34% compared with the disease control group (G2). A delayed type hypersensitivity (DTH) reaction showed that the paw volume was significantly decreased by 114.28% in the Biofield Energy Treated test formulation group (G3) with respect to the G2 group. The platelets count was increased by 61.55% in the Biofield Treated test formulation group (G3) compared to the G2 group. Moreover, the administration of the Biofield Treated herbomineral formulation (G3) group exhibited a decrease in the level of creatinine (9.62%), and uric acid (14.40%), while the level of potassium ion concentration was incresaed by 77.43% compared to the G2 group. Further, the change in body weight, feed consumption, organ to body weight ratio data, and histopathology examination did not suggest any statistical difference, which depicts that the Biofield American Journal of Biomedical and Life Sciences 2017; 5(6): 144-153 145 Energy Treated test formulation was found to be safe. Overall, The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) significantly modulates the immunological parameters of the herbomineral formulation compared with the untreated test formulation. These data suggest that the Biofield Treated test formulation can be used for autoimmune and inflammatory diseases along with stress management and anti-aging by improving overall health.

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“…Similarly, the water intake was measured daily throughout the experiment period. All the data were reported from day 1 to day 23 as per study treatment regimen [45].…”

Section: Determination Of Body Weight Water and Feed Intakementioning

confidence: 99%

Immunopotentiating Impact of The Trivedi Effect®-Biofield Energy Healing on Herbomineral Formulation After Oral Administration in Male Sprague Dawley Rats

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

BIO

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Abstract:A new proprietary herbomineral formulation was formulated, consisting of essential ingredients viz. herbal root extract ashwagandha and minerals (zinc, magnesium, and selenium). The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect ® ) Treatment on the herbomineral formulation in male Sprague Dawley rats. The test formulation was divided into two parts. One part was denoted as the control without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely from twenty renowned Biofield Energy Healers. The experimental parameters studies were humoral immune response (primary and secondary titre), delayed type hypersensitivity reaction, animal weight parameters, feed and water intake, histopathology, hematological and serum biochemistry. Humoral immune response showed the primary and secondary antibody titre values were significantly (p≤0.05) increased by 5.33% and 112.5%, respectively in the Biofield Energy Treated test formulation (G4) group with respect to the disease control group (G2). Delayed type hypersensitivity results showed significant increase in paw edema by 88.24% (p≤0.05) and 25% at 24 and 48 hours of duration, respectively in the Biofield Energy Treated test formulation (G4) group compared with the G2 group. Hematological studies showed a significant increase in the RBC count, hemoglobin, and packed cell volume (PCV), while the platelet count was increased by 8.40% in the Biofield Energy Treated test formulation group (G4) compared with the disease control group (G2). Biochemical analysis exhibited an increased level of calcium and phosphorus by 2.34% and 7.38%, respectively while serum uric acid was significantly decreased by 18.34% along with a slight increase in the magnesium, potassium, and sodium ions in the Biofield Energy Treated test formulation (G4) compared with the G2 group. In conclusion, the Biofield Energy Treated Test Formulation would be the powerful immunomodulatory product, which was found to be safe at the tested doses. Therefore, The Trivedi Effect ® -Biofield Energy Healing based herbomineral formulation can be applied to potentiate the immune system that helps to fight against many infectious diseases. Overall, experimental data suggested that the Biofield

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Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats

Cited by 28 publications

References 39 publications

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

An Investigation of The Trivedi Effect<sup>®</sup>-Energy of Consciousness Healing Treatment to Modulate the Immunomodulatory Effect of Herbomineral Formulation in Male <i>Sprague Dawley</i> Rats

Immunopotentiating Impact of The Trivedi Effect<sup>®</sup>-Biofield Energy Healing on Herbomineral Formulation After Oral Administration in Male <i>Sprague Dawley</i> Rats

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Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats

Cited by 28 publications

References 39 publications

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

An Investigation of The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;-Energy of Consciousness Healing Treatment to Modulate the Immunomodulatory Effect of Herbomineral Formulation in Male &lt;i&gt;Sprague Dawley&lt;/i&gt; Rats

Immunopotentiating Impact of The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;-Biofield Energy Healing on Herbomineral Formulation After Oral Administration in Male &lt;i&gt;Sprague Dawley&lt;/i&gt; Rats

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An Investigation of The Trivedi Effect<sup>®</sup>-Energy of Consciousness Healing Treatment to Modulate the Immunomodulatory Effect of Herbomineral Formulation in Male <i>Sprague Dawley</i> Rats

Immunopotentiating Impact of The Trivedi Effect<sup>®</sup>-Biofield Energy Healing on Herbomineral Formulation After Oral Administration in Male <i>Sprague Dawley</i> Rats