Эпидемиология и прогностические факторы орофарингеального плоскоклеточного рака претерпели серьезные изменения за последние 30 лет. Эти перемены затронули и подходы к специальным методам лечения. В об зоре рассмотрены различные методы лечения-лучевая терапия (ЛТ), химиолучевая терапия (ХЛТ) и химиотерапия (ХТ) рака ротоглотки, а также их влияние на показатели выживаемости больных раком этой локализации. Следует отметить, что отечественные и зарубежные рекомендации не учитывают прогностическую роль вируса па
Acute respiratory disease COVID-19 caused by the SARS-CoV-2 coronavirus demonstrate weak clinical manifestation in most patients. However, pneumonia and acute respiratory distress syndrome in some cases may cause serious problems due to the lack of effective etiotropic and pathogenetic therapy. Presumably, SARS-CoV-2 leads to the delayed type I interferon activation and loss of control over virus replication in the early stages of infection, which is why the adaptive CD8+T-cell response must be controlled to avoid the development of pulmonary pathology. These data should be taken into account when developing strategies for COVID-19 therapy. Mesenchymal stem cells therapy serves as possible treatment opportunity for severe forms of the disease due to their homing, pronounced anti-inflammatory and antifibrotic properties. It was found that in viral infections, including COVID-19, mesenchymal stem cells can synthesize antiviral defense mediators under the influence of interferon causing resistance to viruses. Thus, mesenchymal stem cells are able to provide comprehensive anti-inflammatory protection, which leads to clinical improvement in patients with COVID-19.
The aim – to evaluate the functional state of ocular adnexa and of the eyeball after cryodestruction of benign eyelid and conjunctiva tumors using modern cryosurgical equipment.
Materials and methods. Into the study, 87 patients (87 eyes) were included with eyelid and conjunctiva benign tumors after cryosurgical treatment of atheroma, cyst, papilloma, nevus, granuloma, xanthelasma using an autonomous cryoapplicator of porous permeable titanium nickelide.
Results and conclusions. The study showed a high efficacy of cryogenic treatment method using an autonomous cryoapplicator of porous permeable titanium nickelide. Depending on dimensions of the lesion, exposure duration, and the number of repeated applications at the session, the recovery occurred within 1–2 months without functional defect and healthy tissue injury.
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