Эпидемиология и прогностические факторы орофарингеального плоскоклеточного рака претерпели серьезные изменения за последние 30 лет. Эти перемены затронули и подходы к специальным методам лечения. В обз оре рассмотрены различные методы лечения-лучевая терапия (ЛТ), химиолучевая терапия (ХЛТ) и химиотерапия (ХТ) рака ротоглотки, а также их влияние на показатели выживаемости больных раком этой локализации. Следует отметить, что отечественные и зарубежные рекомендации не учитывают прогностическую роль вируса па
Background Liquid biopsy is a promising method of diagnosing malignant tumors. It allows determining the level of free circulating tumor cells – micrometastases, tumor DNA, microRNA and exosomes in blood plasma, as well as detecting various genetic changes. This work included a literature review of current scientific publications on liquid biopsy techniques indexed in PubMed.Objective The aim of the study was to evaluate the efficacy and peculiarities of this technique in comparison with standard methods of morphological verification of oncological diseases, as well as the feasibility of its use in clinical practice. Compared to tissue biopsy LB has the following advantages: simplicity and speed of examination, easy repeatability and low invasiveness, possibility of dynamic monitoring of tumor progression – general clonal transformation as well as the appearance of resistance to treatment. The disadvantages of this method include low sensitivity, difficulty in proper interpretation of biomarkers and determination of their specificity, high risk of false positive and false negative results due to the presence of dormant tumor cells.Conclusion Currently, liquid biopsy analysis in clinical practice requires standardization and continuous validation.
The aim – to evaluate the functional state of ocular adnexa and of the eyeball after cryodestruction of benign eyelid and conjunctiva tumors using modern cryosurgical equipment.
Materials and methods. Into the study, 87 patients (87 eyes) were included with eyelid and conjunctiva benign tumors after cryosurgical treatment of atheroma, cyst, papilloma, nevus, granuloma, xanthelasma using an autonomous cryoapplicator of porous permeable titanium nickelide.
Results and conclusions. The study showed a high efficacy of cryogenic treatment method using an autonomous cryoapplicator of porous permeable titanium nickelide. Depending on dimensions of the lesion, exposure duration, and the number of repeated applications at the session, the recovery occurred within 1–2 months without functional defect and healthy tissue injury.
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