Despite high variability among the studies, synthesis of available data provided significant evidence of beneficial clinical and immunologic effects of probiotics in the treatment of AR, especially with seasonal AR and LP-33 strains. With the rising pool of studies, the most promising strains in specific allergies can be revealed and adjuvant therapy with probiotics can be recommended for the treatment of AR.

Patients treated with SCIT are at risk of both local and systemic adverse reactions; however, in most cases, symptoms are readily reversible if they are recognized early and treated promptly. The safety profile of SLIT is good; therefore, SLIT can be self-administered by patients in their homes. In this article, we reviewed the efficacy and safety of allergen immunotherapy.

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Medications such as pills are the forms generally used, whereas they have some disadvantages. Slow absorption is the important disadvantage as the onset of action gets pro-longed. In liquid forms of the medication, the delay is avoided. Many drugs do not have enough stability levels in the suspension form. Gastric residence also affects drug delivery

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There are alternative routes and products to improve the efficacy of immunotherapy.

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