Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis

Güvenç, Işıl Adadan; Muluk, Nuray Bayar; Mutlu, Fezan; Eskı, Erkan; Altıntoprak, Niyazi; Öktemer, Tuğba; Cingi, Cemal

doi:10.2500/ajra.2016.30.4354

Cited by 77 publications

(90 citation statements)

References 66 publications

(179 reference statements)

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“…59 Jerzynska et al 59 observed a decrease in symptom-medication score in all groups treated with SLIT. 59 They also demonstrated a significant increase of CD4+CD25+Fox3+ cells in the children receiving SLIT with L rhamnosus compared with children treated with SLIT and vitamin D. 59 A systemic review of the probiotics in the treatment of AR by G€ uvenç et al 60 concluded that significant evidence suggests beneficial clinical and immunologic effects of probiotics. 60 The previously described probiotic clinical trials relied on oral dosing, and research into direct nasal probiotics is scarce.…”

Section: Probiotics In Perennial and Seasonal Allergic Rhinitismentioning

confidence: 99%

The microbiome of the nose

Rawls

Ellis

2019

Annals of Allergy, Asthma & Immunology

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The nasal microbiome is a diverse community of microorganisms that can be found throughout the nose and sinuses. Bacteria in the nose and nasal microbiome profiles can be detected shortly after birth. Staphylococcus aureus is a key pathogenic bacterium in chronic rhinosinusitis with nasal polyps; however, this may dependent on the phenotype and severity of disease. Probiotics can potentially improve clinical efficacy of immunotherapies and antihistamines in treatment plans of allergic rhinitis, but this requires further evidence. Instructions Credit can now be obtained, free for a limited time, by reading the review article and completing all activity components. Please note the instructions listed below: • Review the target audience, learning objectives and all disclosures. • Complete the pre-test. • Read the article and reflect on all content as to how it may be applicable to your practice. • Complete the post-test/evaluation and claim credit earned. At this time, physicians will have earned up to 1.0 AMA PRA Category 1 Credit TM. Minimum passing score on the post-test is 70%. Overall Purpose Participants will be able to demonstrate increased knowledge of the clinical treatment of allergy/asthma/immunology and how new information can be applied to their own practices.

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Section: Probiotics In Perennial and Seasonal Allergic Rhinitismentioning

confidence: 99%

The microbiome of the nose

Rawls

Ellis

2019

Annals of Allergy, Asthma & Immunology

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“…In the current study, a population of MCp in the BM of healthy adults was identified, which was more frequent, and had lower surface expression of integrin β7 than the recently described MCp population in the blood. 3 Integrin β7 is required for transmigration of mouse MCp into the lung. 4 Thus, we speculate that integrin β7 is upregulated on the human MCp upon release from the BM in preparation for their transmigration from the blood to the peripheral tissues.…”

Section: Demonstration Of Human Mast Cell Progenitors In the Bone Marrowmentioning

confidence: 99%

Effect of Lactobacillus plantarum YIT 0132 on Japanese cedar pollinosis and regulatory T cells in adults

Suzuki

Kubota

Kakiyama

et al. 2019

Allergy

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“…QoL was significantly better in a sub-analysis of the Lp-33 lactobacillus strain. However, total nasal and ocular qualityof-life scores were similar to placebo (Table 3) [73]. Conversely, in a meta-analysis of 1,919 patients the positive effect of probiotics on Rhinitis Quality of Life (RQLQ) scores, was significant (SMD: −2.23; 95% CI: −4.07, −0.40) though there was no effect on Rhinitis Total Symptom Scores (RTSS) (SMD −0.36; (95% CI: −0.83, 0.10) (…”

Section: Allergic Rhinitismentioning

confidence: 86%

Immunoactive preparations and regulatory responses in the respiratory tract: potential for clinical application in chronic inflammatory airway diseases

Feleszko

Rossi

Krenke

et al. 2020

Expert Review of Respiratory Medicine

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Introduction: The prevalence of chronic inflammatory airway diseases is rising. Their treatment with corticosteroids increases infection risk, while overuse of antimicrobial agents may increase morbidity and antimicrobial resistance. Nonspecific immunomodulatory compounds alter immune responses to both infectious and atopic challenges. These compounds may offer an alternative approach for symptom reduction and prophylaxis against both infections and exacerbations in chronic inflammatory airway disease. Areas covered: We assessed the available data on the efficacy of nonspecific immunomodulators including bacterial lysates, synthetic compounds, and vaccines in chronic rhinosinusitis (CRS); allergic and non-allergic rhinitis; chronic obstructive pulmonary disease (COPD), and asthma. A search of PubMed was carried out using the 'Clinical Trials' filter for each condition and immunomodulatory product detailed below, where available, data from meta-analyses were reported. Expert opinion: Pre-clinical data has revealed a coherent mechanistic path of action for oral immunomodulators on the respiratory immune system, principally via the gut-lung immune axis. In patients with asthma, allergic rhinitis, CRS, and COPD immunomodulatory therapy reduces symptoms, exacerbations, hospitalizations, and drug consumption. However, data are heterogeneous, and study quality remains limited. A lack of high-quality recent trials remains the major unmet research need in the field. ARTICLE HISTORY

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Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis

Cited by 77 publications

References 66 publications

The microbiome of the nose

The microbiome of the nose

Effect of Lactobacillus plantarum YIT 0132 on Japanese cedar pollinosis and regulatory T cells in adults

Immunoactive preparations and regulatory responses in the respiratory tract: potential for clinical application in chronic inflammatory airway diseases

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