Alternative Products to Treat Allergic Rhinitis and Alternative Routes for Allergy Immunotherapy

Ipci, Kagan; Öktemer, Tuğba; Muluk, Nuray Bayar; Şahin, Ethem; Altıntoprak, Niyazi; Bafaqeeh, Sameer Ali; Kurt, Yasemin Turgut; Mladina, Ranko; Šubarić, Marin; Cingi, Cemal

doi:10.2500/ajra.2016.30.4364

Cited by 10 publications

(3 citation statements)

References 39 publications

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“…Since the 1990s, CP has gained extensive clinical application in the preventative management of AR and hay fever worldwide [15, 16]. However, few studies have directly explored the impact of CP on mucociliary clearance.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency

Zhou

Zuo

et al. 2018

Int Arch Allergy Immunol

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Background: Cellulose powder (CP) has been reported as a safe and effective complementary treatment for allergic rhinitis (AR). Currently, CP has gained increasing application for clinical management worldwide, particularly in China. However, studies focusing on the effect of CP on normal human nasal epithelial cells (hNECs) and ciliary function are lacking. Here, we aimed to explore the adverse effects of CP on the activity and ciliary function of hNECs. Methods: We biopsied ethmoid sinus or middle turbinate tissues during surgical resection from control subjects who underwent endoscopic sinus surgery for diseases other than AR. Cells were isolated and passaged, followed by differentiation in an air-liquid interface (ALI). Flow cytometry and cell viability test (cell counting kit-8) were performed to detect the cytotoxicity of CP (effects on cell proliferation) on normal hNECs. By using the ALI culture model, we investigated the effects of CP on ciliary beat frequency (CBF). Results: There was a significant reduction in hNEC count at high concentrations of CP (2.5 mg/mL) at days 3 and 7 (both p < 0.05). As the concentration increased, cell death increased progressively from day 3 to day 7. However, these effects were not evident at low concentrations (0.25 mg/mL, p > 0.05). High-dose CP (2.5 mg) significantly reduced the CBF (p < 0.05). At lower concentrations (0.25–2.5 mg/mL), CP initially increased but subsequently reduced the CBF of hNECs compared with control group. Conclusions: Cytotoxicity and the suppression of ciliary beat at high concentrations justify more prudent use of CP for the management of AR.

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Section: Discussionmentioning

confidence: 99%

Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency

Zhou

Zuo

et al. 2018

Int Arch Allergy Immunol

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“…[8,22]. The use of black cumin oil in suppressing allergic reactions is associated with the probable antihistamine properties of the oil and the inhibition of enzymes responsible for the metabolism of arachidonic acid [23,24].…”

Section: Advances In Engineering Research Volume 151mentioning

confidence: 99%

Recycling and Standardization Aspects of Nigella sativa in the Food Industr

Егорова¹,

Резніченко²,

Ermolaeva³

2018

International Scientific and Practical Conference "AgroSMART - Smart Solutions for Agriculture" (AgroSMART 2018)

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Black cumin seeds and products of its processingbutter and semi-skimmed flour-have high nutritional and market value. At the same time, there are no unified state or international requirements and standard methodologies for confirming the authenticity and quality of butter, flour and food products that include them. The aim of this work is to analyze data on the composition of black cumin oil and flour and justify the list of regulated indicators and methods for confirming their authenticity and quality. The paper analyzes data on the chemical composition of black cumin oil. The limits of the content of the most physiologically important fatty acids-Linoleic, Linolenic and Eicosadienoic-are recommended for standardization and confirmation of the authenticity of fatty oil; standardization method is recommended. Data on the content of terpenes in the essential black cumin oil is summarized, the variability of the composition and content of the prevailing terpenes is shown. According to the results of studies of black cumin seed flour, a list of regulated organoleptic and physico-chemical indicators of the quality of this food raw material has been proposed.

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“…Further, numerous studies have shown that neuroendocrine immunity (NEI) plays a important role in AR [25,26] and acupuncture may affect the function of the NEI system to treat AR. [13,[27][28][29].…”

mentioning

confidence: 99%

Acupuncture methods for allergic rhinitis: a systematic review and bayesian meta-analysis of randomized controlled trials

Yin

Geng

et al. 2020

Chin Med

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Background Allergic rhinitis (AR) is a common symptomatic, inflammatory, and immunological disorder of nasal mucosa. Multiple clinical trials and systematic reviews have implicated acupuncture methods as potentially effective treatment strategies for AR, however, considering the great burden of AR, it is crucial to explore the most recent clinical evidence supporting acupuncture in AR. Besides, the methodologies reported in previous studies as well as those commonly applied during clinical practices greatly vary. Herein, we conducted network meta-analysis to compare the effectiveness of diverse acupuncture methods for AR treatment. Methods We conducted a literature search for relevant reports published from inception to 1 July 2020 in several scientific databases, including PubMed, Embase, Cochrane library, Web of Science, CNKI, WF, VIP, CBM, AMED as well as related registration platforms. Primary outcomes as reported in the identified studies were assessed using nasal symptoms. All Meta-analyses were performed with RevMan, ADDIS, and STATA software. To ensure consistency among our reviewers, the intra-class correlation coefficient was used. Results Exactly 39 studies with 3433 participants were covered in this meta-analysis. The meta-analysis demonstrated that all acupuncture types were superior to sham acupuncture in terms of total nasal symptom score and rhinoconjunctivitis quality of life questionnaire. Moxibustion was recommended as the most effective intervention as it reduced nasal symptoms in 6 treatments. On the other hand, manual acupuncture plus conventional medicine was recommended as the most effective intervention in improving the quality of life in 9 treatments. Notably, moxibustion was recommended as the most effective intervention that changed the content of IgE in 9 treatments. Moreover, adverse events of these interventions were acceptable. Conclusion Our findings revealed that all acupuncture methods are effective and safe for AR. Moreover, either moxibustion or manual acupuncture plus conventional medicine are potentially the most effective treatment strategies for AR. Based on these findings, it is evident that acupuncture therapy is not inferior to pharmacologic therapy. Therefore, for AR patients who are either unresponsive to conventional medicine or are intolerant to adverse events, acupuncture therapy should be administered. However, the quality of these included trials was mainly ranked as moderate quality, we recommend additional well-designed RCTs with larger sample sizes to validate these findings.

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Alternative Products to Treat Allergic Rhinitis and Alternative Routes for Allergy Immunotherapy

Abstract: There are alternative routes and products to improve the efficacy of immunotherapy.

Cited by 10 publications

References 39 publications

Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency

Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency

Recycling and Standardization Aspects of Nigella sativa in the Food Industr

Acupuncture methods for allergic rhinitis: a systematic review and bayesian meta-analysis of randomized controlled trials

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