According to ideomotor theory, voluntary actions are selected and initiated by means of anticipated action effects. Prior experiments yielded evidence for these effect anticipations with response-effect (R-E) compatibility phenomena using blocked R-E relations. Daily actions, however, typically evoke different effects depending on the situational context. In the present study, we accounted for this natural variability and investigated R-E compatibility effects by a trial-by-trial variation of R-E compatibility relations. In line with recent observations regarding ideomotor learning, R-E compatibility influenced responding only when participants responded in free choice trials assuming that participants then adopted an intention-based action control mode. In contrast, R-E compatibility had no impact when participants responded according to imperative stimuli throughout the experiment, thus when participants adopted a stimulus-based action control mode. Interestingly, once an intention-based mode was established because of free choice trials within an experimental block, we observed response compatibility effects in free as well as forced choice trials. These findings extend and refine theoretical assumptions on different action control modes in goal-directed behavior and the specific contribution of ideomotor processes to intention-based action control.
Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk. Finally, we summarize the existing evidence for both pharmacotherapy and psychotherapy of depression in demented patients. There is an urgent need for large-scale collaborative research to elucidate the role and interplay of clinical and biological features in elderly individuals with depressive disorders who are at elevated risk for developing dementia. To overcome barriers for successful drug development, we propose the introduction of the precision medicine paradigm to this research field.
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