Obesity is has become a major problem worldwide. Since 1975, the prevalence of obesity nearly trippled, and nowadays we are facing an obesity epidemic. Obesity is a major risk factor for many diseases such as cardiovascular ones (mainly heart disease and stroke) -being the leading cause of death worldwide, musculoskeletal disorders or type 2 diabetes mellitus (DM).
Rheumatoid arthritis (RA) is the most widespread inflammatory rheumatic disease with about 10% of all rheumatic diseases and a global prevalence of about 1%. Through its features - joint proliferation, articular panic, articular cartilage degradation and bone erosion � RA has a destructive and disabling character and a major socio-economic impact. Osteoporosis is a bone system disease characterized by loss of bone mass and alteration of bone architecture, with consequences on bone fragility correlated with an increased fracture risk. With a major socio-economic impact, the World Health Organization (WHO) has declared osteoporosis as a public health problem, third on cardiovascular and oncological.
Teriparatide (TPT) is the active 1-34 amino acid sequence with osteoanabolic use for severe osteoporosis. Our aim is to analyze the biochemical and clinical profile of patients treated with TPT based on Romanian protocol. The inclusion and exclusion criteria are based on specific country protocol for TPT 20 �g/day, for 2 years, once in life time based on self administration. This is a transversal study including data of a tertiary centre of endocrinology on patients who signed the informed consent. This is a real life study, of observational type (the intervention meaning the TPT recommendation was done by individual decision of each clinician). Normal total and ionic calcium is associated with low 25-hydroxyvitamin D levels and a mean lumbar T-score of -3.1�0.7SD. 50% of patients treated with TPT have digestive conditions, less than 10% are first time users, a high severity profile is based on a median of 4 years regarding prior anti-osteoporotic medication and of 3 previous fragility fractures.
L'indice d'adiposité viscérale (IAV) -marqueur potentiel du risque cardio-métabolique L'importance du risque cardiovasculaire/cardio-métabolique est particulière car le contrôle de ses composantes peut affecter l'athérogenèse et ses conséquences cliniques: la cardiopathie ischémique, la maladie cérébrovasculaire, l'artériopathie périphérique et le diabète sucré (DS). Pour évaluer le risque cardio-métabolique associé à l'obésité viscérale, on a essayé d'identifier un indicateur utile dans la pratique clinique. L'indice d'adiposité viscérale (IAV) pourrait devenir un outil facile à utiliser dans la pratique quotidienne qui met en évidence le risque cardio-métabolique. IAV indique la fonction du tissu adipeux viscéral et sa croissance est indépendamment corrélée aux risques cardiovasculaire et cérébrovasculaire. Le monde médical a essayé d'identifier un moyen facile d'évaluer le risque cardiovasculaire, de sorte que l'indice d'adiposité viscérale, dont la formule inclut un certain nombre de facteurs de risque cardiovasculaires, ait été introduit.
Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Type 1 diabetes is occurred most frequently in childhood and adolescence, although in recent years due to the increase in the prevalence of obesity in this category of population has been registered a growing number of cases of type 2 diabetes among children and adolescents (1, 2).
Metabolic syndrome (MS) is defined as a complex entity that involves the accumulation of cardiovascular and metabolic risk factors represented by: abdominal obesity, insulin resistance, hypertension, dyslipidemia [1]. The presence of MS correlates with the risk of cardiovascular disease in people without diabetes mellitus (DM), as well as those with type 2 DM [2-8].Visceral adipose tissue is an active metabolic organ and abdominal obesity is an independent risk factor for metabolic disorder present in MS [9,10,11], associated with the development of cardiovascular disease and type 2 diabetes in children, adolescents and adults [12-15]. Our findings have shown an association of visceral adiposity index (VAI) with MS in both men and women with prediabetes and diabetes, these findings allow us to conclude that VAI is a simple but effective indicator for estimating the presence of MS among adults.
Anorexia, as a symptom, is part of the complex picture of a large pediatric pathology. Through attentive observation, anorexia as a single sign, may announce the onset of serious and particular affections. In all 4 cases, anorexia was a singular sign for a period of time before the complete illness was established. Whether adenoid cyst, cerebral abscess, pontocerebellar atrophy, Wilms tumor, neuroendocrine system of hunger regulation, satiety, complex control achieved through interactions of the limbic-hypothalamus-cortex system, come into operation with the occurrence of organic anorexia, different of the psychogenic anorexia (usually common in adolescents). The study is an alarm signal on the importance of a symptom in early diagnosis, and the rapid establishment of therapy in severe life threatening conditions.
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