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A simple, sensitive and rapid spectrophotometric method for the determination of chloramphenicol in pure as well as in dosage form is described. The method is based on the reaction of reduced chloramphenicol with o-chloranil in an aqueous alkaline medium to form a purple colored charge transfer complex of maximum absorption peak at 527 nm. Under the optimized reaction conditions, Beer's law correlating the absorbance with chloramphenicol concentration was obeyed in the range of 2-65 μg ml-1 with molar absorptivity 3.72×10 3 L mol −1 cm −1. The limits of detection and quantitation were 0.456 and 1.521 μg ml-1 , respectively.

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