Spectrophotometric determination of microgram amounts of vitamin B1 with chloranil

Al-Ghabsha, Thabit S.; Rahim, S.A.; Al-Sabha, Theia'a N.

doi:10.1016/0026-265x(86)90106-2

Cited by 11 publications

(4 citation statements)

References 9 publications

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“…It is unclear why, when mixed with the NBOMe drug, the presence would influence the final color change result. The literature has shown that some compounds with similar functional groups (carboxylic acids and alcohols) may interfere with the reaction between the amine group of the drug and the benzoquinone 53,54 . Even with these small differences, the color changes seen would still indicate the presence of a drug, potentially 25‐NBOMe, and would require further testing.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Clancy

Philp

Shimmon

et al. 2020

Drug Testing and Analysis

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The great increase of new psychoactive substances over the past decade has substantially transformed the illicit drug industry to an ever-changing dynamic market. 25-NBOMe compounds are just one of these new substance groups that pose a public health risk in many countries around the world. These highly potent, hallucinogenic phenethylamines have previously been sold as "legal highs" or "synthetic LSD" and the necessity to rapidly identify their presence is crucial.While there are many laboratory-based analytical methods capable of identifying these compounds, the lack of presumptive test methods indicates the need for a specific and timely test that could be used in the field. Herein we outline the developed chemical spot test that can selectively identify the presence of 25-NBOMe compounds and related analogs through the reaction with a substituted benzoquinone reagent under basic conditions. This test method has been comprehensively validated showing a high level of selectivity, specificity, and precision with only two other illicit substances producing similar positive results as 25-NBOMe and few false-negative results seen. The working limit of detection was determined to be 225 μg and there was no cross-reactivity from potential adulterants of significance. This test has also been shown to work directly with blotter papers containing 25-NBOMe compounds, indicating no interference from this common matrix and the ability to differentiate these compounds from LSD. This method shows a high potential to be translated to a field compatible test that is simple, rapid, and selective for 25-NBOMe compounds.

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Section: Resultsmentioning

confidence: 99%

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Clancy

Philp

Shimmon

et al. 2020

Drug Testing and Analysis

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show abstract

“…The detection limit is lower by 2 -3 orders of magnitude than that from UV-spectrophotometry 4 and other usual spectrophotometric methods, such as Bromothymol Blue and p-methylaminophenol sulfate, 5 diazo salt of 6-aminothymol, 6 diazotized 4-hydroazinobenzenesulfonic acid 7 and tetrachlorobenzoquinone. 31 Thus, the RRS method has high sensitivity.…”

Section: Relation Between the Rrs Intensity And The Concentration Of Vitamin B1mentioning

confidence: 99%

Resonance Rayleigh-Scattering Method for the Determination of Vitamin B1 with Methyl Orange

Liu¹,

Zhang²,

Luo³

et al. 2002

ANAL. SCI.

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In a pH 2.3-3.0 acid medium, the resonance Rayleigh scattering (RRS) intensity is greatly enhanced when vitamin B, reacts with Methyl Orange to form an ion-association complex. The maximum RRS peak appears at 588 nm, another higher peak is at 403 nm and there are two smaller RRS peaks at 800 nm and 288 nm. The RRS intensity is directly proportional to the concentration of vitamin B, in the range of 0-400 ng ml(-1). The method has high sensitivity and the detection limit (3sigma) for vitamin B1 is 7.2 ng ml(-1). The effects of coexisting substances on the determination of vitamin B, were investigated, and the results show that this method has good selectivity and can be applied to the direct determination of vitamin B1 in composite vitamin B tablets and multivitamin tablet samples.

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“…The determination of vitamin B 1 has been performed in the recent decade by chromatographic [1][2][3][4][5][6], spectrophotometric [7,8], injection procedures with various kinds of signal detection [9][10][11][12]. Also the method with nanoparticles as a probe by resonance Rayleigh scattering (RRS) [13] and others techniques [14,15] have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Design of a Vitamin B₁‐Selective Electrode Based on an Ion‐Pair and Its Application to Pharmaceutical Analysis

et al. 2010

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Vitamin B 1 -selective electrodes with PVC membrane were developed that contain ion associates of vitamin B 1 with an inorganic anion, BiI 4 À , and an organic anion, brilliant yellow, as electrode-active substances. The linearity ranges of the electrode function are 1.0 10 À5 -1.0 10 À2 and 1.0 10 À4 -1.0 10 À2 M, the electrode function slopes are 33.0 AE 1.0 and 33.1 AE 1.1 mV decade À1 , the detection limits are 5.5 10 À6 and 8.3 10 À5 M for BiI 4 À and brilliant yellow respectively. The working range of pH is 5-12. The efficiency of the use of electrodes for the vitamin B 1 content control in multivitamin pharmaceutical preparations was shown by direct potentiometry and potentiometric titration methods.

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Spectrophotometric determination of microgram amounts of vitamin B1 with chloranil

Cited by 11 publications

References 9 publications

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Resonance Rayleigh-Scattering Method for the Determination of Vitamin B1 with Methyl Orange

Design of a Vitamin B₁‐Selective Electrode Based on an Ion‐Pair and Its Application to Pharmaceutical Analysis

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Spectrophotometric determination of microgram amounts of vitamin B1 with chloranil

Cited by 11 publications

References 9 publications

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Development and validation of a color spot test method for the presumptive detection of 25‐NBOMe compounds

Resonance Rayleigh-Scattering Method for the Determination of Vitamin B1 with Methyl Orange

Design of a Vitamin B1‐Selective Electrode Based on an Ion‐Pair and Its Application to Pharmaceutical Analysis

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Design of a Vitamin B₁‐Selective Electrode Based on an Ion‐Pair and Its Application to Pharmaceutical Analysis