A novel diclofenac ion-selective electrode has been prepared and used in pharmaceutical analysis. The ion-associate of diclofenac with basic dye (crystal violet) was used as the membrane carrier. Among the four different solvent mediators tested, dibutylphthalate (DBP) exhibited proper behavior including the Nernstian slope of the calibration curve, fast response time and good reproducibility of the emf values. The electrode exhibits a Nernstian slope of 59 ± 1 mV decade -1 for diclofenac in the concentration range 5.0 × 10 -5 -5.0 × 10 -2 M with the limit of detection of 2.5 × 10 -5 M. The electrode displays good sensitivity with the respect to a number of common inorganic and organic species. It can be used in a pH range of 6-11. The membrane sensor was successfully applied to the determination of diclofenac in capsules and for its recovery from urine samples.
A new simple, rapid and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium (Dicl) in pharmaceutical preparations. This method is based on the reaction of diclofenac sodium with an analytical reagent 1,3,3‐trimethyl‐5‐thiocyanato‐2‐[3‐(1′,3′,3′‐trimethyl‐3′‐H‐indol‐2′‐ylidene)‐propenyl]‐indolium cloride (TIC) at pH 8.0‐11.0 and the extraction of ion associate colored complex. Optimal conditions for the complex formation between Dicl and TIC were studied. This ion associate complex (1:1) was detected and extracted with toluene and an absorption maximum at 566.2 nm against a blank reagent. The calibration graph was linear from 0.9‐11.0 μg/mL of diclofenac and the detection limit was 0.86 μg/mL.
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