Extraction and Spectrophotometric Determination of Diclofenac in Pharmaceuticals

Abstract

A new simple, rapid and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium (Dicl) in pharmaceutical preparations. This method is based on the reaction of diclofenac sodium with an analytical reagent 1,3,3‐trimethyl‐5‐thiocyanato‐2‐[3‐(1′,3′,3′‐trimethyl‐3′‐H‐indol‐2′‐ylidene)‐propenyl]‐indolium cloride (TIC) at pH 8.0‐11.0 and the extraction of ion associate colored complex. Optimal conditions for the complex formation between Dicl and TIC were studied. This ion associate complex (1:1) was detected and extracted with toluene and an absorption maximum at 566.2 nm against a blank reagent. The calibration graph was linear from 0.9‐11.0 μg/mL of diclofenac and the detection limit was 0.86 μg/mL.

Enhanced adsorptive removal of diclofenac sodium from aqueous solution by bentonite-supported nanoscale zero-valent iron

“…Diclofenac sodium (DCF) (Figure 1), a 2-[(2, 6dichlorophenyl) amino] benzene acetic acid, monosodium salt, is widely used as a nonsteroidal antiinflammatory pharmaceutical drug (Beltr an, Pocostales, Alvarez, & Oropesa, 2009;Kormosh, Hunka, & Bazel, 2008;Kumar, Shankar, & Singh, 2011;Patil & Chaudhari, 2012). Additionally, DCF has been detected in water resources and wastewater treatment plant effluents in concentrations up to lg L À1 (Zuccato, Calamari, Natangelo, & Fanelli, 2000).…”

Quantification and Classification of Diclofenac Sodium Content in Dispersed Commercially Available Tablets by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis

“…and the United States Pharmacopoeia (USP) includes the dispersion of the standard compound in anhydrous acetic acid followed by titration with perchloric acid and potentiometric determination of the endpoint [ 8 , 9 ], while for the determination of DS in slow-release tablets, the USP proposes its dispersion in a methanol–water mixture (70:30) and subsequent analysis in a liquid chromatograph with a UV detector, using methanol and phosphate buffer (pH 2.5) as mobile phase components [ 10 ]. In recent decades, several analytical methods have been developed for the determination of diclofenac in drug products, including spectrophotometric [ 7 , 11 , 12 , 13 , 14 , 15 , 16 ], spectroscopic [ 17 , 18 , 19 , 20 , 21 ], fluorimetric [ 22 ], potentiometric [ 22 , 23 , 24 , 25 , 26 , 27 ], and chromatographic methods [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Degradation of Plasticized Poly(1-chloroethylene) Waterproofing Membranes used as a Building Material

“…1 The properties of PVC can be significantly improved by adding plasticizers to make it more flexible and durable, which greatly expands its applications. 2,3 Plasticized PVC membranes are among the most commonly used waterproofing materials for roofing and geotechnical applications. However, practice shows that roofing membranes undergo chemical and physical changes when exposed to the combined effects of heat from solar radiation, near ultraviolet radiation, atmospheric oxidation, moisture and air pollution over long periods of time.…”