Spectrophotometric determination of piroxicam

Kormosh, Zholt O.; Hunka, Iryna; Bazeľ, Yaroslav

doi:10.1134/s1061934811020079

Cited by 23 publications

(12 citation statements)

References 27 publications

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“…The development and application of ion-selective electrodes for pharmaceutical analysis continue to be of interest because these sensors offer the advantage of simple design and operation, reasonable selectivity, wide dynamic range, low cost, fast response, applicability to colored and turbid solutions and possible interface with automated and computerized systems [4,5]. For these advantages, ISEs found various applications in clinical chemistry, in environmental protection, in agricultural, in foodstuff samples and in analytical chemistry [6].…”

Section: Introductionmentioning

confidence: 99%

A New Approach for Decreasing the Detection Limit of Gentamicin Ion‐selective Electrodes by Incorporation of Multiwall Carbon Nanotubes (MWCNTs)/Lipophilic Anionic Additives

Khalil

El-aziz

2016

Electroanalysis

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Two novel carbon paste electrodes based on gentamicin‐reineckate (GNS‐RN)/multiwall carbon nanotubes (MWCNTs)/sodium tetraphenyl borate (NaTPB) or potassium tetraphenylborate (KTPB) for potentiometric determination of gentamicin sulfate were constructed. Our endeavors of lowering the detection limit for gentamicin ion‐selective electrodes were described. The paper focused on gentamicin carbon paste electrodes based on GNS‐RN as electroactive material, o‐nitrophenyloctyl ether (o‐NPOE) as plasticizer and incorporation of MWCNTs and lipophilic anionic additives (NaTPB and KTPB) which lower the detection limit of the electrodes showing best results for determination of gentamicin ion. The characteristics of the electrodes, GNS‐RN+NaTPB+MWCNTs (sensor 1) and GNS‐RN+KTPB+ MWCNTs (sensor 2), were measured, showing favorable features as they provided measurements of the potential with near‐Nernstian slopes of 29.6±0.3 and 29.1±0.3 mV/decade over the concentration range of 1.0×10−6–1.0×10−2 mol L−1 and pH ranges 3.0–8.2 and 3.0–8.0 in short response times (6.5 sec). Importantly, the electrodes had low detection limits of 3.0×10−7and 3.4×10−7 mol L−1 for the two sensors, respectively. The sensors showed high selectivity for gentamicin ion with respect to a large number of interfering species. The electrodes were successfully applied for the potentiometric determination of GNS ions in pure state, pharmaceutical preparations and human urine with high accuracy and precision. The results of this study were compared with some previously published data using other analytical methods.

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Section: Introductionmentioning

confidence: 99%

A New Approach for Decreasing the Detection Limit of Gentamicin Ion‐selective Electrodes by Incorporation of Multiwall Carbon Nanotubes (MWCNTs)/Lipophilic Anionic Additives

Khalil

El-aziz

2016

Electroanalysis

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“…Several analytical methods have been described for the estimation of ENRO or PIRO alone or combined with other drugs in pharmaceutical formulations. Studies have employed high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), UV spectrophotometry, spectrofluorimetry, infrared spectroscopy, potentiometry, voltammetry, phosphorimetry, or chemiluminescence (Batrawi, Wahdan, Al-Rimawi, 2017;Starek et al, 2009;Kormosh, Hunka, Bazel, 2011;Ulu, 2009;Golovnev, Vasiliev, Kiriki, 2012;Khaled et al, 2012;Ensaifi, Khayamian, Taei, 2009;Souza et al, 2013;Pulgarin, Molina, Munoz, 2011).…”

Section: Introductionmentioning

confidence: 99%

Stability-indicating HPLC-DAD method for the simultaneous determination of fluoroquinolone in combination with a non-steroidal anti-inflammatory drug in pharmaceutical formulation

Araujo

Rosa

Amaral

et al. 2020

Braz. J. Pharm. Sci.

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We developed and validated a stability-indicating assay method for the simultaneous determination of enrofloxacin and piroxicam in combination and in the presence of degradation products. Reversephase high-performance liquid chromatography analyses were carried out on a Vertisep C18 column and acetonitrile-water (48:52 v/v, pH 3.0) mobile phase with a 1.00 mL min −1 flow rate. The efficient chromatographic separation of these drugs and their forced degradation products was achieved in less than 5 min with a peak purity match factor higher than 950. The method used showed linearity in the concentration ranges of 0.25 to 16.0 μg mL −1 for enrofloxacin (r = 0.9997) and 0.125 to 8.0 μg mL −1 for piroxicam (r = 0.9999) as well as precision (relative standard deviation lower than 2%), accuracy (mean recovery 100 ± 2%), and robustness, according to ICH (International Conference on Harmonization) and AOAC (Association of Official Analytical Chemists) guidelines. This method can simultaneously determine the combination of these drugs in a veterinary formulation and separate the drug peaks from their forced degradation products. Additionally, its optimized chromatographic conditions can contribute to the quality control of this formulation in pharmaceutical manufacturing plants and minimize waste from the organic solvent.

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“…The acidity of the medium may affect the state of an ion associate and other membrane components. 25 In order to study the effect of pH on the performance of the sensor, the potentials were determined at two concentrations (1.0 × 10 −3 ; 1.0 × 10 −4 M) of (PDL) ++ ions as a function of pH. The pH of the solution was varied by the addition of NaOH and HCl.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Sensor for the Selective Determination of Prindopril Based on Phosphotungestic Acid Plastic Membrane

Zаrеh¹,

Wasel²,

Alkreem³

2013

Bulletin of the Korean Chemical Society

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A novel PVC membrane sensor for perindopril based on perindopril-phosphotungstate ion pair complex was prepared. The influence of membrane composition (i.e. percent of PVC, plasticizer, ion-pair complex, and kind of plasticizer), inner solution, pH of test solution and foreign cations on the electrode performance was investigated. The optimized membrane demonstrates Nernstian response (30.9 ± 1.0 mV per decade) for perindopril cations over a wide linear range from 9.0 × 10 −7 to 1 × 10 −2 M at 25 o C. The potentiometric response is independent of the pH in the range of 4.0-9.5. The proposed sensor has the advantages of easy preparation, fast response time. The selectivity coefficients indicate excellent selectivity for perindopril over many common cations (e.g., Na, rhamnose, maltose, glycine and benzamide. The practical applications of this electrode was demonstrated by measuring the concentrations of perindopril in pure solutions and pharmaceutical preparations with satisfactory results.

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Spectrophotometric determination of piroxicam

Cited by 23 publications

References 27 publications

A New Approach for Decreasing the Detection Limit of Gentamicin Ion‐selective Electrodes by Incorporation of Multiwall Carbon Nanotubes (MWCNTs)/Lipophilic Anionic Additives

A New Approach for Decreasing the Detection Limit of Gentamicin Ion‐selective Electrodes by Incorporation of Multiwall Carbon Nanotubes (MWCNTs)/Lipophilic Anionic Additives

Stability-indicating HPLC-DAD method for the simultaneous determination of fluoroquinolone in combination with a non-steroidal anti-inflammatory drug in pharmaceutical formulation

Electrochemical Sensor for the Selective Determination of Prindopril Based on Phosphotungestic Acid Plastic Membrane

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