A New Approach for Decreasing the Detection Limit of Gentamicin Ion‐selective Electrodes by Incorporation of Multiwall Carbon Nanotubes (MWCNTs)/Lipophilic Anionic Additives
Abstract:Two novel carbon paste electrodes based on gentamicin‐reineckate (GNS‐RN)/multiwall carbon nanotubes (MWCNTs)/sodium tetraphenyl borate (NaTPB) or potassium tetraphenylborate (KTPB) for potentiometric determination of gentamicin sulfate were constructed. Our endeavors of lowering the detection limit for gentamicin ion‐selective electrodes were described. The paper focused on gentamicin carbon paste electrodes based on GNS‐RN as electroactive material, o‐nitrophenyloctyl ether (o‐NPOE) as plasticizer and incorp… Show more
“…[15] For example, carbon paste electrodes (CPEs) including high surface area carbon nanomaterials (carbon nano tubes, graphene) incorporated with antibiotics ions, have been demonstrated with high sensing performance. [16,17] However, the limited selectivity of carbon nanomaterials due to the lack of functional groups, and hydrophobicity hinders their application in biological samples. In this regard, nanomaterials having functional groups could solve the selectivity issue as well as the wettability issue for enabling higher sensing performance.…”
Abstract3D continuous mesoscale architectures of nanomaterials possess the potential to revolutionize real‐time electrochemical biosensing through higher active site density and improved accessibility for cell proliferation. Herein, 3D microporous Ti3C2TX MXene biosensors are fabricated to monitor antibiotic release in tissue engineering scaffolds. The Ti3C2TX‐coated 3D electrodes are prepared by conformal MXene deposition on 3D‐printed polymer microlattices. The Ti3C2TX MXene coating facilitates direct electron transfer, leading to the efficient detection of common antibiotics such as gentamicin and vancomycin. The 3D microporous architecture exposes greater electrochemically active MXene surface area, resulting in remarkable sensitivity for detecting gentamicin (10–1 mM) and vancomycin (100–1 mM), 1000 times more sensitive than control electrodes composed of 2D planar films of Ti3C2TX MXene. To characterize the suitability of 3D microporous Ti3C2TX MXene sensors for monitoring drug elution in bone tissue regeneration applications, osteoblast‐like (MG‐63) cells are seeded on the 3D MXene microlattices for 3, 5, and 7 days. Cell proliferation on the 3D microporous MXene is tracked over 7 days, demonstrating its promising biocompatibility and its clinical translation potential. Thus, 3D microporous Ti3C2TX MXene can provide a platform for mediator‐free biosensing, enabling new applications for in vivo monitoring of drug elution.
“…[15] For example, carbon paste electrodes (CPEs) including high surface area carbon nanomaterials (carbon nano tubes, graphene) incorporated with antibiotics ions, have been demonstrated with high sensing performance. [16,17] However, the limited selectivity of carbon nanomaterials due to the lack of functional groups, and hydrophobicity hinders their application in biological samples. In this regard, nanomaterials having functional groups could solve the selectivity issue as well as the wettability issue for enabling higher sensing performance.…”
Abstract3D continuous mesoscale architectures of nanomaterials possess the potential to revolutionize real‐time electrochemical biosensing through higher active site density and improved accessibility for cell proliferation. Herein, 3D microporous Ti3C2TX MXene biosensors are fabricated to monitor antibiotic release in tissue engineering scaffolds. The Ti3C2TX‐coated 3D electrodes are prepared by conformal MXene deposition on 3D‐printed polymer microlattices. The Ti3C2TX MXene coating facilitates direct electron transfer, leading to the efficient detection of common antibiotics such as gentamicin and vancomycin. The 3D microporous architecture exposes greater electrochemically active MXene surface area, resulting in remarkable sensitivity for detecting gentamicin (10–1 mM) and vancomycin (100–1 mM), 1000 times more sensitive than control electrodes composed of 2D planar films of Ti3C2TX MXene. To characterize the suitability of 3D microporous Ti3C2TX MXene sensors for monitoring drug elution in bone tissue regeneration applications, osteoblast‐like (MG‐63) cells are seeded on the 3D MXene microlattices for 3, 5, and 7 days. Cell proliferation on the 3D microporous MXene is tracked over 7 days, demonstrating its promising biocompatibility and its clinical translation potential. Thus, 3D microporous Ti3C2TX MXene can provide a platform for mediator‐free biosensing, enabling new applications for in vivo monitoring of drug elution.
“…In fact, the discovery of carbon nanotubes [20] has opened the horizons for broad application in electrochemistry [21–23] due to their remarkable features such as high thermal conductivity, metallic or semi‐metallic behavior, ultra‐light weight, mechanical strength, large surface‐to‐volume ratio, and high electrical conductivity [24, 25]; indicating the ability of these materials to facilitate a more effective electronic transfer. Consequently, CNT‐based sensors had faster electron transfer kinetics, lower detection limit, and higher sensitivity compared with conventional sensors [26–34].…”
Two sensitive and selective potentiometric sensors based on zinc‐iron layered double hydroxides/multiwalled carbon nanotubes (Zn−Fe LDH/MWCNTs) (sensor I) and graphene/multiwalled carbon nanotubes (Gr/MWCNTs) (sensor II) nanocomposites were developed for benzydamine hydrochloride (Benz) determination. The investigated sensors displayed excellent Nernstian slopes 58.5±0.7 and 59.5±0.5 mV decade−1, detection limits 8.3×10−7 and 1.9×10−7 mol L−1, long lifetimes, adequate selectivity, high chemical, and thermal stability within pH range of 2.4–8.5 for sensors І and ІІ, respectively. The surface morphology of sensors was analyzed using a Transmission Electron Microscope (TEM). The analytical method was efficiently implemented for Benz determination in biological fluids and surface water samples.
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