Application of promethazine hydrochloride as a chromogenic reagent for the spectrophotometric determination of aniline and its substituents

Al-Abachi, Mouayed Q.; Al-Ghabsha, Thabit S.; Salih, Elham

doi:10.1016/0026-265x(90)90096-n

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…The stoichiometry of the reaction was studied using equimolar concentrations of the drugs and DNPH at constant sodium periodate and sodium hydroxide concentrations, adopting Jop‫ۥ‬ s method of continuous variation [40], a molar ratio of 1:1 drugs to DNPH was obtained by the applied method as shown in Fig.(3). The stability constants of the dye products were calculated [41] by comparing the absorbance of a solution containing stoichiometric amount of PHP or AMOX and DNPH with that of solution containing fivefold excess of DNPH reagent. The stability constants of the dye products in water under the described experimental conditions were 1.843 x10 5 and 3.75 x 10 5 l mol − 1 for each of PHP and AMOX respectively.…”

Section: Batch Spectrophotometric Determinationmentioning

confidence: 99%

Flow injection-Spectrophotometric Determination of Phenylephrine Hydrochloride and Amoxicillin Trihydrate in Pharmaceutical Preparations

Al-Abachi¹,

Subhi²

2013

JNUS

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A batch and flow injection (FI) spectrophotometric methods have been developed for the determination of phenylephrine hydrochloride (PHP) and amoxicillin trihydrate (AMOX) in pharmaceutical preparations. The methods are based on coupling reaction of 2,4dinitrophenylhydrazine (DNPH) with either PHP or AMOX in the presence of sodium hydroxide to form a red colored water-soluble products with absorption maxima at 525 and 515 nm for PHP and AMOX respectively. Optimum conditions for determining the drugs were investigated. Beer's law were obeyed over the concentration ranges of 2-50μg/ml PHP and 1-40 μg/ml AMOX for batch method, and of 30-1000 μg/ml PHP and50-1200μg/ml AMOX for FIA method. The limits of detection were 1.044 μg/ml PHP and 0.230 μg/ml AMOX for batch method, and for FI method were 14.21 μg/ml PHP and 34.00 μg/ml AMOX. The proposed methods were applied satisfactorilyto the determination of PHP and AMOX in pharmaceutical preparations. The procedures are characterized by its simplicity, accuracy and precision. The results obtained were in good agreement with those obtained using reference standard methods at the 95% confidence level.

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Section: Batch Spectrophotometric Determinationmentioning

confidence: 99%

Flow injection-Spectrophotometric Determination of Phenylephrine Hydrochloride and Amoxicillin Trihydrate in Pharmaceutical Preparations

Al-Abachi¹,

Subhi²

2013

JNUS

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“…The most serious and potentially lethal effect of chloramphenicol is a plastic anemia (4). Several methods have been reported for the determination of CAP including titration (5),spectrophotometry (2,(6)(7)(8)biosensor immunoassay (9), gas chromatography (10,11) , liquid chromatography-mass spectrometry (12),liquid chromatography-electrospray ionisation tandem mass spectrometry (13,14),enzyme-liquid immunosorbent assay (15)(16)(17), molecularly imprinted polymer for HPLC (1), chemiluminescences (18), differential-pulse polagraphy (19) and derivative spectrophotometry (20). Among the various methods available for the determination of the drug, spectrophotometry continues to be very popular, because of its simplicity, specificity and low cost.…”

Section: Fig1 Structure Of Chloramphenicolmentioning

confidence: 99%

Spectrophotometric Determination of Chloramphenicol in Pharmaceutical Preparations

Hamoudi¹,

Bashir²

2018

J.Edu.Sci.

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‫عند‬ ‫وتمتص‬ ‫المحمول‬ 606 ً ‫مساويا‬ ‫ية‬ ‫الر‬ ‫المو‬ ‫اإلمتصاصية‬ ‫كانت‬ ‫إذ‬ ‫عالية‬ ‫وبحساسية‬ ‫نانوميتر‬ ‫إلى‬ 1.2.2 10 4 × ‫لتر.مول‬ -1 ‫.سم‬ -1 ‫إلى‬ ‫مساوية‬ ‫ساندل‬ ‫وداللة‬ 0.020 ‫ام/سم‬ ‫مايكروغر‬ 2 ‫ووجد‬ ‫الترك‬ ‫من‬ ‫مدى‬ ‫عمى‬ ‫ينطبق‬ ‫بير‬ ‫قانون‬ ‫أن‬ ‫بين‬ ‫ما‬ ‫يز‬ 0.0 ‫إلى‬ 12 ‫الخطأ‬ ‫كان‬ ‫و‬ ‫جزء/مميون.‬ ‫بين‬ ‫ما‬ ‫النسبي‬ -2.73 ‫إلى‬ + 0.37 ‫بين‬ ‫ما‬ ‫النسبي‬ ‫القياسي‬ ‫اف‬ ‫االنحر‬ ‫و‬ % ±3.84 ‫إلى‬ ±0.44 ‫امفينكول‬ ‫الكمور‬ ‫تقدير‬ ‫في‬ ‫بنجاح‬ ‫يقة‬ ‫الطر‬ ‫طبقت‬ ‫وقد‬ ‫التركيز،‬ ‫مستوى‬ ‫عمى‬ ً ‫اعتمادا‬ ،% ‫ال‬ ‫ومرهم‬ ‫العين‬ ‫ة‬ ‫وقطر‬ ‫(كبسول‬ ‫الصيدالنية‬ ‫ات‬ ‫المستحضر‬ ‫في‬ ‫عين).‬ AbstractA spectrophotometric method for the determination of trace amounts of chloramphenicol has been proposed. This method depends upon the reduction of the nitro to amino group, condensation with promethazine reagent in the presence of cerium (IV) ions to form a colored dye which exhibits maximum absorption at 606 nm with a high sensitivity (molar absorptivity is 1.292×10 4 l.mol -1 .cm -1 , and Sandell's sensitivity index of 0.025 µg/cm 2 ). Beer' s law is applied within the concentration range of obeyed in 0.4 to 12 ppm with a relative error of -2.73 to + 0.37% and a relative standard deviation of ± 3.84 to ± 0.44%, depending on the concentration level. The method has been successfully applied to the

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“…The stability constant of the dye products was calculated [20] by comparing the absorbance of a solution containing stoichiometric amount of VHC and DMCP (3.365×10 -4 M) with that of solution containing five-fold excess of DMCP reagent. The stability constant of the dye products in water under the described experimental conditions was 1.303 ×10 5 L.mol -1 .…”

Section: Fig(4) Effect Of Volume Of Hcl Dmcp and Naoh On The Absorbmentioning

confidence: 99%

Flow Injection- Spectrophotometric Determination of Vancomycin Hydrochloride in Pharmaceutical Preparations Using Diazotized Metoclopramide

Al-Abachi

Hadi

Yousef

2015

JNUS

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A batch and flow injection analysis (FIA) spectrophotometric methods have been developed for the determination of vancomycin hydrochloride (VHC) in aqueous solution and in pharmaceutical preparations. The methods are based on the reaction of VHC with diazotized metoclopramide (DMCP) in alkaline medium. The water soluble yellowish-orange color product was measured at λmax 451 nm. Linearity was observed from 0.5 to 100 and 1 to 550 µg mL −1 of VHC with detection limits of 0.230 and 0.419 µg mL −1 by batch and FIA procedure respectively. The sampling rate was 128 injections per hour for flow injection methods. The effects of chemical and physical parameters have been carefully considered and the proposed procedures were successfully applied to the determination of VHC in pharmaceutical formulations.

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Application of promethazine hydrochloride as a chromogenic reagent for the spectrophotometric determination of aniline and its substituents

Cited by 11 publications

References 6 publications

Flow injection-Spectrophotometric Determination of Phenylephrine Hydrochloride and Amoxicillin Trihydrate in Pharmaceutical Preparations

Flow injection-Spectrophotometric Determination of Phenylephrine Hydrochloride and Amoxicillin Trihydrate in Pharmaceutical Preparations

Spectrophotometric Determination of Chloramphenicol in Pharmaceutical Preparations

Flow Injection- Spectrophotometric Determination of Vancomycin Hydrochloride in Pharmaceutical Preparations Using Diazotized Metoclopramide

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