A direct simple, rapid and sensitive spectrophotometric method has been developed for the determination of domperidone maleate (DOM), carvedilol (CAR), dimetindene maleate (DIM), and cinnarizine (CIN) in bluk and pharmaceutical formulations. The method was based on the formation of ion association complexes between the studied drugs and erythrosine B dye in citrate buffer solution (pH4.5), which show maximum absorbance at 555 nm for DOM or in acetate buffer solution (pH5-5.3) and measure the absorbance at 556, 556, 555 nm for CAR, DIM and CIN respectively. The method obeyed Beer , s law in the concentration range 0.5-20 µg/ml with molar absorptivity 3.70×10 4 , 3.43×10 4 , 2.62×10 4 , and 3.53×10 4 l.mol -1 .cm -1 for DOM, CAR, DIM and CIN respectively. The accuracy (average recovery) was ranged between 99.47 and 101.27% and precision (RSD%) is less than 3.04%. The method has been successfully applied for the determination of studied drugs in pharmaceutical formulations with no interferences. The results were in agood agreement with certified value, official method and standard addition procedure.
An indirect simple and sensitive spectrophotometric method has been developed for the determination of famotidine (FAM) and ciprofloxacin hydrochloride (CIP) in pure and pharmaceutical dosages. The method is based on the oxidation of FAM and CIP with known excess of N-Bromosuccinimde in acidic medium and subsequent occupation of unreacted oxidant in decolorization of Janus green B dye and measure the absorbance of residual dye at 618 nm. Calibration curves of residual Janus green B dye in the presence of FAM or CIP were rectilinear over the ranges 1.0-10.0 and 1.0-7.5 µg/ml with molar absorptivity 3.61×10 4 and 5.14×10 4 l.mol -1 .cm -1 respectively. The accuracy (average recovery) was ranged between 99.68 and 100.23% and precision (RSD%) is less than 3.80%. The developed method was successfully applied for the determination of the studied drugs in their pharmaceutical preparations. The results obtained are in agreement with certified values of pharmaceutical preparations and also with standard addition procedure and standard method applied in state company for drugs industry and medical appliance,SDI.
A simple, sensitive and accurate spectrophotometric method has been developed for the determination of salbutamol sulphate (SAB) and isoxsuprine hydrochloride (ISX) in pure and pharmaceutical dosage. The method involved oxidation of (SAB) and (ISX) with a known excess of N-bromosuccinamid in acidic medium, and subsequent occupation of unreacted oxidant in decolorization of Evans blue dye (EB). This, in the presence of SAB or ISX was rectilinear over the ranges 1.0-12.0, 1.0-11.0 µg/mL, with molar absorptivity 4.21×10 4 and 2.58×10 4 l.mol -1 .cm -1 respectively. The developed method had been successfully applied for the determination of the studied drugs in their pharmaceutical dosage resulting in a good agreement with certified value and standard addition procedure.
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