Spectrophotometric Determination of Domperidone Maleate, Carvedilol, Dimetindene Maleate and Cinnarizine in Pharmaceuticals by Ion Association Complex Formation with Erythrosine B Dye

Abstract

A direct simple, rapid and sensitive spectrophotometric method has been developed for the determination of domperidone maleate (DOM), carvedilol (CAR), dimetindene maleate (DIM), and cinnarizine (CIN) in bluk and pharmaceutical formulations. The method was based on the formation of ion association complexes between the studied drugs and erythrosine B dye in citrate buffer solution (pH4.5), which show maximum absorbance at 555 nm for DOM or in acetate buffer solution (pH5-5.3) and measure the absorbance at 556, 556, 555 nm for CAR, DIM and CIN respectively. The method obeyed Beer , s law in the concentration range 0.5-20 µg/ml with molar absorptivity 3.70×10 4 , 3.43×10 4 , 2.62×10 4 , and 3.53×10 4 l.mol -1 .cm -1 for DOM, CAR, DIM and CIN respectively. The accuracy (average recovery) was ranged between 99.47 and 101.27% and precision (RSD%) is less than 3.04%. The method has been successfully applied for the determination of studied drugs in pharmaceutical formulations with no interferences. The results were in agood agreement with certified value, official method and standard addition procedure.

Plant extract mediated synthesis of ZnO and CeO2 nanoparticles for spectrofluorometric assay of omeprazole and domperidone in pharmaceuticals

“…Various analytical methods, such as spectrophotometric methods [ [4] , [5] , [6] , [7] ], spectrofluorometric methods [ 8 , 9 ], electrochemical determination methods including voltammetric approaches [ 10 , 11 ], as well as different chromatographic separation techniques [ 12 , 13 ], have been described for the determination of the drugs under study.…”

Spectrofluorometric determination of orphenadrine, dimenhydrinate, and cinnarizine using direct and synchronous techniques with greenness assessment

“…At the same time, versatile analytical techniques could be used for the estimation of ORP, like RP-HPLC 13 , 14 , derivative spectrophotometry 15 – 17 , liquid chromatography mass spectrometry/mass spectrometry (LC–MS/MS) 18 , and chemometric methods 19 . Different analytical techniques have been employed to determine CNN, such as reverse phase-high performance liquid chromatography (RP-HPLC) 20 , derivatization spectrophotometric technique 21 – 23 , spectrofluorimetry 24 , 25 , and voltametric technique 26 . Both DMN and CNN were estimated by thin layer chromatography (TLC), RP-HPLC methods 7 , 9 .…”