In the present work, a novel sensitive electrochemical carbon paste electrode chemically modified with yttrium doped manganese oxide Mn 2 O 3 /Y 2 O 3 nanostructures was assigned for determination of marbofloxacin (MRB) using square wave voltammetry (SWV) method. MRB has a broad spectrum of bactericidal activity for the treatment of urinary, respiratory and dermatological diseases in bovines and their retention in animal meats and milk leads to adverse side effects for the consumer. Thus a rapid estimation of minor concentrations of MRB has exerted a great concern to ensure food safety. XRD, EDX, Raman spectroscopy, SEM, and TEM techniques were employed to characterize the samples. The electrochemical oxidation behavior of MRB shows irreversible anodic peak at 1.10 V vs Ag/AgCl, in Britton-Robinson buffer (BR) at pH 5.0. The relationship was rectilinear over the range 10 × 10 −9 -1.0 × 10 −4 M between the peak current and its related concentration with a minimum detection limit of 2.4 × 10 −9 M. The developed method was green chemistry challenges and successfully applied to assay the drug in its dosage form, bovine meat and milk samples with a good recovery lies between 94.56% and 105.33% with relative standard deviation less than 10%.
Elbasvir and grazoprevir combination is newly approved for treatment of patients infected with hepatitis C virus. In the present work, a highly sensitive, selective and accurate second derivative synchronous fluorescence...
In the present work, a sensitive optimized electrochemical screen-printed electrode chemically modified with cerium nanoparticles was assigned for the determination of oxymetazoline hydrochloride. The sensing membrane was based on incorporation of ion paring agent i.e. tetraphenylborate associated with the drug as an electroactive material. Asides, paraffin oil was used as a pasting liquid for in this screen-printed electrode whereas cerium nanoparticles, commonly known as nanoceria, were used as oxide ion conductors to increase the electrode surface area and electrical conductivity. Optimization of the experimental parameters was performed using a response surface methodology which enables a graphical clarification of the linkage between different experimental factors and the slope response. The modified sensor with cerium nanoparticles displays a stable and significant linear response with a reproducible potential for five months at Nernstian slope of 59.07 ± 0.76 mV decade−1 over the concentration range (5 × 10−6−1 × 10−2 mol.l−1) at 25 ± oC with a detection limit of 9.72 × 10−7 mol l−1. Furthermore, the proposed approach was successfully used for the analysis of the drug in its pure and dosage form.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.