Development and validation of a highly sensitive second derivative synchronous fluorescence spectroscopic method for the simultaneous determination of elbasvir and grazoprevir in pharmaceutical preparation and human plasma

Abstract

Elbasvir and grazoprevir combination is newly approved for treatment of patients infected with hepatitis C virus. In the present work, a highly sensitive, selective and accurate second derivative synchronous fluorescence...

Quantitative analysis of favipiravir and hydroxychloroquine as FDA‐approved drugs for treatment of COVID‐19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids

“…[ 37 ] It also can be used to quantitatively determine several medicines in a single run due to its small, precise, and sharp spectrum. [ 36 , 38 , 39 , 40 , 41 ]…”

“…[37] It also can be used to quantitatively determine several medicines in a single run due to its small, precise, and sharp spectrum. [36,[38][39][40][41] To date, no method for the simultaneous quantification of FPV and HCQ as co-administered drugs in biological fluids has been documented. This necessitates the establishment of a responsive F I G U R E 1 Chemical structure of (a) favipiravir and (b) hydroxychloroquine sulphate procedure for simultaneous estimation of both drugs for their therapeutic drug monitoring.…”

Green adherent spectrophotometric determination of molnupiravir based on computational calculations; application to a recently FDA-approved pharmaceutical dosage form

“…Computational chemistry represents an integral approach, in HPLC [4] , [5] , spectrophotometry [6] , [7] and electrochemistry [8] , to the development of greener methods based on theoretical testing of compound interactions and reducing the use of toxic solvents [9] . Many analytical methods have been developed to demonstrate the quality of the drug materials including HPLC [10] , TLC [11] , specroflorimetry [12] , [13] , [14] , [15] , [16] , [17] as well as spectrophotometry [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] . Table 1.…”

Green fitted second derivative synchronous spectrofluorometric method for simultaneous determination of remdesivir and apixaban at Nano gram scale in the spiked human plasma

“…In addition, the mathematical derivation of the synchronous spectra can help in spectral resolution of multi-components in different mixtures. Previous reports have described the use of synchronous fluorescence spectroscopy scanning for the determination of drugs in mixtures in different matrices, including pharmaceutical form or plasma matrix [12] , [13] , [14] . [12] , [13] , [14] .…”