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The massification of the university education is inevitable process nowadays. On the one hand it allows solving the problem of knowledge generation and dissemination. On the other hand it helps individuals to achieve the subjective wellbeing, which is based on acquisition of knowledge that is necessary for the professional and individual orientation. In this article authors made an attempt to set tendency between individual's participation in the educational process and the acquisition of wellbeing's state. Taking into account modern trend of continuous education, authors as well suppose the existence of permanent wellbeing state. This statement is partially proven by social surveys and research's data, which has been conducted in Russia, Brazil, South Africa and other countries. Attractiveness and accessibility of education for people from different social groups determine the future level of public education. The rapid technological development of society, accessibility and mass character of educational programs, unconscious strivings of the major part of society to wellbeing must inevitably lead to the growth of average citizen's accomplishment.

A study on the Russian trotting breeds was conducted to assess the impact of horses' sporting results and the degree of accumulation of chemical elements in the hair. In the first phase of the research, the elemental composition of the mane hair of trotter horses (n = 215) was studied. Based on these studies, percentile intervals for the distribution of concentrations of chemical elements in the hair have been established, and the values of 25 and 75 percentile adopted as a "physiological standard" have been defined. In the second stage of the research into clinically healthy Russian trotting breeds (n = 56), it was estimated that the sporting results were dependent on the elemental status defined by the hair. The elemental composition of the hair was defined by 25 chemical elements using atomic emission and mass spectrometry. It is established that the mane hair is closely related to the sporting results of trotter horses. Thus, in animal wool with the highest sporting achievements, there were reliably less I, Cr, Co, Li, V, Al, Pb, and Cd, and reliably more Si than the low ones. Differences in individual elements exceeded 200%. As sporting performance diminished, the number of elements within the standard increased. For example, for mares with average speed, there were deviations from the physiological standard by 6 elements (P, Fe, Mn, I, Co, Si), with the low one by 13 elements (P, Fe, Cu, Mn, I, Co, Si, K, Cr, Ni, V, Al, Pb). A comparative estimate of the mineralization of the horses' mane measured by the sum of the amount of substances showed that there was a negative correlation between the accumulation of toxic elements and the speed (r = - 0.59). On the basis of the above, a conclusion is reached on the future use of the mane hair to assess the speed qualities of trotter horses.

The paper describes the preconditions and specifics of electronic learning resources in Russian universities and focuses on the priorities in the development of electronic education. As it is revealed, there are certain problems with employing electronic resources in mixed forms of learning, i.e. when such resources are only a part of the educational process, not a complete substitute. The paper explores the advantages and shortcomings of electronic learning in full-time instruction basing on the outcomes of a survey for students and teachers carried out in one the Russian universities. These outcomes help to assess the effectiveness of electronic learning and further perspectives of mixed forms of instruction. The paper finally provides some recommendations on how to increase the effectiveness of electronic learning by means of its integration with traditional technologies in education.

Abstract.In the article the definition of the term "corporate culture of the university" is refined and supplemented. It is noted that the traditional understanding does not reflect the fundamental changes taking place in the education system and interpersonal relationships of teachers and students of the university, and that undoubtedly have a significant influence on the corporate culture of the university formation

The Thoroughbred (TB) horse has hugely impacted the development of horse breeding around the world. This breed has unique genetic qualities due to having had a closed studbook for approximately 300 years. In Russia, TBs have been bred since the second half of the 18th century. Here, we analyzed the genetic diversity and the inbreeding level in TB horses (n = 9680) for the period from 1990 to 2018 using polymorphisms of 17 microsatellite loci. We found that the genetic structure of the TB breed in Russia is represented by 100 alleles of panel STR (short tandem repeat) loci and has been stable for the past three decades. The conducted monitoring revealed a slight increase in the Wright’s inbreeding coefficient in all age and sex groups of TB horses (stallions, broodmares, and foals) from 0.68% to 0.90%, which was followed by a decrease in the degree of heterozygosity, Ho, from 68.5% to 67.6%. The Spearman’s rank correlation coefficient between the level of inbreeding and the degree of homozygosity was estimated (r = 0.022; p > 0.05). The obtained data on the DNA genotypes of horses of different breeds provide a unique base for the evaluation of genetic variability and the control of genetic variability of horses in selection programs.

The study of the elemental composition of biosubstrates of horses of heavy breeds in the system blood-milk-wool was undertaken. The average values of the exchange pool of 6 toxic (aluminum, arsenic, cadmium, mercury, lead, tin) and 13 essential elements (calcium, potassium, manganese, sodium, phosphorus, cobalt, chromium, copper, iron, iodine, magnesium, selenium and zinc) in the body of lactating horses were determined. Comparison of the concentration of toxic elements in various horse nutrient depots showed a significant positive correlation with individual essential nutrients.

Conjugates of carbon nanoparticles and aptamers have great potential in many areas of biomedicine. In order to be implemented in practice, such conjugates should keep their properties throughout long storage period in commonly available conditions. In this work, we prepared conjugates of carbon nanoparticles (CNP) with DNA aptamers using streptavidin-biotin reaction. Obtained conjugates possess superior stability and kept their physical-chemical and functional properties during 30 days at +4 °C and -20 °C. Proposed approach to conjugation allows loading of about 100-120 pM of biotinylated aptamer per 1 mg of streptavidin-coated CNP (CNP-Str). Aptamer-functionalized CNP-Str have zeta potential of -34 mV at pH 7, mean diameter of 168-177 nm, and polydispersity index of 0.080-0.140. High reproducibility of functionalization was confirmed by preparation of several batches of CNP-aptamer with the same size distribution and aptamer loading using independently synthesized parent CNP-Str nanoparticles. Stability of CNP-aptamer conjugates was significantly enhanced by postsynthesis addition of EDTA that prevents nuclease degradation of immobilized aptamers. Obtained nanoparticles were stable at pH ranging from 6 to 10. Optical properties of CNP-aptamer nanoparticles were also studied and their ability to quench fluorescence via Förster resonance energy transfer was shown. Taking into account properties of CNP-aptamer conjugates, we suppose they may be used in both homo- and heterogeneous colorimetric, fluorescent, and aggregation-based assays.