Objective: The main objective of the present investigation was to design, prepare and evaluate moisturizing cream using sunflower wax.Methods: In the present work 32 full factorial design was applied to study the effect of varying concentration of independent variables stearic acid (X1) and sunflower wax (X2) on dependent variables viscosity and spreadability. All of the prepared formulations of moisturizing cream were evaluated for its physicochemical parameters. Further, the optimized formulation and selected commercial moisturizer compared and evaluated for its physicochemical parameters like pH, particle size, spreadability, viscosity and in vitro occlusivity test.Results: Nine different formulations of the moisturizing cream were prepared and all the findings obtained were within the prescribed limit. When compared to the prototype formulation of cream, the formulation MF5 showed good viscosity, in vitro occlusivity and spreadability. From the nine different formulations, MF5 containing 2 % stearic acid and 2 % sunflower was chosen as the optimized formula. Optimization was done on the basis of in vitro occlusivity studies and physicochemical parameters.Conclusion: The results obtained in this research work clearly showed a promising potential of moisturizing cream containing a specific ratio of stearic acid and sunflower wax as emulsifiers. Thus it can be concluded that sunflower wax is incorporated in the moisturizing cream, to avail of its cosmetic benefits.
Objective: The objective of the present work was to formulate and evaluate ointment using sunflower wax.
Methods: In the present work, ointment formulations were prepared using sunflower wax by fusion technique. Sunflower wax base was compared with standard base for its pH, appearance, strength, spreadability, water number, and washability. Further, the optimized formulation was prepared with 2% salicylic acid and evaluated for its physicochemical parameters, compatibility study, drug content, in vitro drug diffusion, ex vivo permeability, and skin irritation test using rat skin.
Results: All of the prepared formulations of ointments were evaluated for its physicochemical parameters and all the findings obtained were within the prescribed limit. As compared to the ointment prepared by prototype formulae as per USP and IP, the formulation F3 containing 97% white petrolatum and 3% of sunflower wax showed good viscosity, strength, and spreadability. Based on viscosity, strength, and spreadability, formulation F3 was chosen as an optimized formulation.
Conclusion: The ointment consisting of white petroleum base 97% and 3% sunflower wax can be used for topical and systemic delivery of active ingredient salicylic acid. The results showed that sunflower wax can be used in ointment base as far as its pharmaceutical properties are concerned. It can effectively replace comparatively costlier available ointment bases.
In current study we attempted mixed solvency approach for solubility enhancement of poorly water soluble drug, ofloxacin. Various hydrotropic agents including sodium benzoate, urea, sodium citrate, sodium acetate, niaciniamide, Lignocaine hydrochloride, PEG6000, PEG-400 were evaluated under study for enhancing solubility of drug. Further effect of various blends of these hydrotropic agents on solubility of ofloxacin was studied. Aqueous injection of ofloxacin was prepared and evaluated for its antimicrobial effectiveness and stability. It was found that mixed solvency approach is useful in solubility enhancement of ofloxacin without affecting its antimicrobial properties.
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