Cocrystallization of Etodolac: Prediction of Cocrystallization, Synthesis, Solid State Characterization And In Vitro Drug Release

Solubility Enhancement of Lornoxicam by Crystal Engineering

“…The mixtures were then ground for 20 min in an agate mortar with a pestle. The milling time was kept short to avoid any degradation of the materials [18,19] . The melting point of raw materials and cocrystals were determined by the capillary method.…”

“…In this methodology, a thin glass capillary tube containing the substance to be determined was introduced into a heated stand (liquid paraffin) in close proximity to a high accuracy thermometer. The temperature in the heating stand was raised at a fixed rate until the sample in the tube transitioned into the liquid state [19] . Drug content was estimated by dissolving weighed quantities of cocrystals in 5% w/v aqueous N,Ndimethylformamide in triplicate.…”

“…The batches were prepared by 2 2 factorial experimental designs [19] . Formulae for 4 experimental batches were given in Table 1.…”

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development

“…On the one hand, cocrystals are unexpectedly formed during processing [118][119][120] while on the other researchers will require the cautious selection of cocrystal design approach as in some cases, cocrystals are not formed as per predictions which indicate challenges in formulating cocrystals. 137 Cocrystal's ability to flourish desired physicochemical and biopharmaceutical properties of API to the optimal extent open a new landscape to Cocrystals of multiple active ingredients can be formulated as fixed dose combinations for better therapeutic applications. It will stimulate investigation of old API's to see new benefits.…”

Crystal Engineering of Antiviral Agent Efavirenz for Solubility Enhancement

“…Hansen solubility parameters of EFV and FA were computed by using the group contribution method following the collective utilization models of Fedors and Van Krevelen-Hoftyzer. The solubility parameter components were computed from group contributions (F) and molar volume (Vm), using the following equations where δd represent dispersion forces energy, δp represents polar forces energy and δh represents hydrogen bonding energy 16,17 .…”