Formulation and Evaluation of Moisturizing Cream Containing Sunflower Wax

Maru, Avish D.; Lahoti, Swaroop R.

doi:10.22159/ijpps.2018v10i11.28645

Cited by 26 publications

(25 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Modern researchers involved in topical semi-solid dosage forms quality assessment use a limited set of techniques to test the spreadability (various modifications of the parallel-plate method or the "slip and drag" method are most often used) [5][6][7][8][9][10][11][12][13][14][15]. In each same study, the conditions of the experiment are often subjected to significant or minor changes (parameters such as the exposure time of the load, the mass of the load, the mass of the dosage form, and the size of the glass plates).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dermatologic Gels Spreadability Measuring Methods Comparative Study

et al. 2022

Int J App Pharm

View full text Add to dashboard Cite

Objective: The main objective of our study is the comprehensive analysis and characterization of the existing spreadability evaluation strategies, the comparison of the obtained results reproducibility and convergence through the example of the 9 most widely used dermatological gels. Methods: Dolobene®, Flucinar®, Ketorol®, Contractubex®, Dr. Theiss Venen gel®, Solcoseryl®, Deep Relief®, Hepatrombin® pharmacopoeia gel samples were analyzed using parallel-plate, “slip and drag”, and viscometry methods. Analysis was performed in flow mode at 32±0.2 °C, over shear rates ranging from 0 to 350 s−1, increasing over a period of 120 s, and was maintained at the superior limit for 10 s and then decreased during the same period. At least 5 replicates of each sample were evaluated, and the upward flow curves were fitted using the Casson mathematical model. Results: Solcoseryl® and Dolobene® showed the best spreadability in the parallel-plate method (3115.66±50.00 and 3316.63±50.00, respectively); Contractubex® and Dolobene showed the best spreadability in the “slip and drag” test (73.46±0.5 and 18.32±0.5, respectively); Solcoseryl® and Contractubex® showed the best spreadability in the viscometry test (43.86±0.5 and 76.92±0.5, respectively). Conclusion: This study analyzed the existing methods for determining the spreadability using commercially available samples of the dermatological gels as examples. The viscometric and the "Slip and drag" methods use different characteristics of spreadability, giving a complex evaluation of the measured parameter in vitro. Therefore, the combination of these two methods has the greatest prospects for reliable determination of this indicator.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A weight (50-500 g) of 125 g is placed on top for 1 minute. Then the diameter of the sample between the plates is measured [7][8][9][10][11].…”

Section: Parallel-plate Methodsmentioning

confidence: 99%

Dermatologic Gels Spreadability Measuring Methods Comparative Study

et al. 2022

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Plain Finasteride gel and FSD loaded NLCs gel was evaluated for its occlusivity by measuring the percent water loss [26,27]. 50 ml Distilled water was placed in different 100 ml beakers.…”

Section: In Vitro Occlusivity Testmentioning

confidence: 99%

A Novel Nanogel Formulation of Finasteride for Topical Treatment of Androgenetic Alopecia: Design, Characterization and in Vitro Evaluation

Sanganabhatla

Sunder

2021

Int J App Pharm

View full text Add to dashboard Cite

Objective: The present paper describes the development and evaluation of a Novel Finasteride (FSD) nanogel topical delivery for the treatment of Androgenetic Alopecia. Nano-based topical formulation was chosen to enhance the solubility, permeability, biocompatibility of drug and to overcome the problems associated with the oral delivery of finasteride. Methods: Various trails batches were prepared by using probe sonication method. Based on stability studies and particle size, NP4 trail was optimized which exhibited a spherical shape with a mean diameter of 113.80±0.72, the polydispersity of 0.28±0.01, zeta potential of-25.2 mV, drug entrapment efficiency of 92.67±0.47 %, and drug loading of 6.15±0.02 %. Storage stability studies demonstrated that the particle size and entrapment efficiency were not changed during 3 mo both at 4 °C and room temperature. Finasteride (FSD) NLCs were characterized for particle size by scanning electron microscope (SEM), chemical state by X-Ray diffraction (XRD), physical stability by centrifugation and thermodynamic stability by Freeze-thaw method. These prepared nanoparticles were transformed into topical nanogel and further evaluated. Results: Among the different trails, C2 trail of NLC gel has shown excellent gelling capacity, clear appearance, good viscosity characteristics and was selected for further evaluation studies. Batches of topical nanogel were characterized through pH, homogeneity, spreadability, viscosity, drug content and in vitro drug release study. Based on pH (6.5-6.8), drug content (91.25±0.9%), spreadability (6.7 cm/sec), C2 batch was subjected to In vitro skin occlusivity study, in-vitro release study and In vitro heamolysis study. Conclusion: The percent cumulative drug release for Finasteride (FSD) gel was found to be 758.52±1.49 µg at 24 h which is quite higher than plain gel and Finasteride (FSD) gel showed maximum occlusiveness and excellent spreadability and found to be stable. In conclusion, prepared Finasteride (FSD) Nanogel could be used with promising potential for the treatment of Androgenetic Alopecia.

show abstract

“…With the help of string attached to the hook and the time (in seconds) required by the top slide to cover a distance of 7.5 cm be noted. A shorter interval indicates better spreadability [19,20]. Spreadability was measured using the equation:…”

Section: Spreadabilitymentioning

confidence: 99%

Formulation and Evaluation of Herbal Oil-Based Itraconazole Cream for Fungal Infection

Kumar¹,

Thakur²,

Sharma³

et al. 2020

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The current study was to formulate and to evaluate itraconazole herbal oil-based cream for fungal infection. Methods: Six herbal oils were used for the formulation of itraconazole creams, namely, mustard oil (MO), olive oil (OO), wheat germ oil (WGO), jojoba oil (JO), tea tree oil (TTO), and combined oil (CO). Creams were formulated by the trituration method. Each herbal oils containing three different formulations of different concentrations of oils. Results: All the prepared formulation was evaluated successfully. Out of all the formulations from each herbal oils the best two formulations were finalized, that is, MO2 and CO2 which show the greater in vitro diffusion rate among all. Formulation MO2 shows 55.45±0.10% and CO2 showed 59.43±1.18% within 480 min, respectively. Optimized formulations were also compared with the marketed formulation, which results in formulation CO2 as the best formulation among all. Conclusion: It can be concluded that herbal oil-based cream proved better alternate than oral preparation and improve patient compliance, ease of administration, local bioavailability, and better proves for fungal infected patients.

show abstract

Formulation and Evaluation of Moisturizing Cream Containing Sunflower Wax

Cited by 26 publications

References 18 publications

Dermatologic Gels Spreadability Measuring Methods Comparative Study

Dermatologic Gels Spreadability Measuring Methods Comparative Study

A Novel Nanogel Formulation of Finasteride for Topical Treatment of Androgenetic Alopecia: Design, Characterization and in Vitro Evaluation

Formulation and Evaluation of Herbal Oil-Based Itraconazole Cream for Fungal Infection

Contact Info

Product

Resources

About