In this paper, present the appropriate tools for the balanced development of maritime and inland waterway transport in Ukraine to ensure the implementation of the country’s economic, social and environmental plans. Using statistical data, the main indicators of the development of waterway transport in Ukraine are systematized, which indicate a lack of a technical base for a high-quality and balanced development of waterway transport in Ukraine, irrational use of the territory and water area of ports, their infrastructure, transport routes, as well as a decrease in business entities, which negatively affects the economy country. This points to the need to stimulate the development of waterway transport to increase the number of jobs, improve living conditions of the population, curb migration processes and retain qualified personnel, unload land transport, and save money on road repairs. Therefore, in order to ensure the implementation of the country’s economic, social and environmental plans, an instrumental-logical model has been developed to ensure the co-evolutionary balanced development of water transport in Ukraine, which is based on the use of institutional, legal, financial, economic and information and communication tools.
Background. Inhaled hypertonic saline solutions (IHSS) are included in the list of mandatory prescriptions in the treatment of cystic fibrosis (CF). However, some patients with CF may develop bronchial hyperreactivity (BHR), which may be the cause of violation of the treatment protocol. The purpose is to study the state of bronchial reactivity to IHSS and its dependence on the clinical, functional and microbiological features of CF course in children. Materials and methods. Forty children with CF were examined. All of them underwent general clinical, molecular genetic, laboratory and microbiological examination. Instrumental methods included spirometry, measurement of fractional exhaled nitric oxide, X-ray and computer tomography of the chest. To determine the individual tolerance of inhalations of hypertonic sodium chloride solution (HSCS), the research protocol proposed by E.P. Dellon et al. was used. Results. According to the results of the research protocol, 17 (42.5 %) patients with CF had BHR to HSCS. The highest frequency of BHR was found in children with a severe CF course. There was no dependence of BHR in CF patients on allergic pathology and a burdened allergic history. Assessment of the tolerance of HSCS before prescribing basic therapy is important. Early functional signs of BHR, which may require the preventive administration of short-acting β2-agonists when using HSCS in children with CF, are as follows: reduction in forced expiratory volume in 1 second by 7 % and maximal expiratory flow at 25 % by 6 % when using 3% HSCS. Conclusions. The presence of BHR in patients with CF may interfere with adequate basic therapy by inhalation. The prescription of IHSS to patients with CF should be personalized with the determination of individual sensitivity of a person to predict a positive therapeutic effect.
The armed aggression of the Russian Federation against Ukraine led to the destruction of critical infrastructure, the termination of port operations in Ukraine, the disruption of regional logistics, the rise in fuel prices, and the increase in ship and cargo insurance costs. It contributed to the restriction of trade in the Black Sea region. The armed aggression of the Russian Federation against Ukraine hinders trade and changes logistics in and throughout the Black Sea region. As a result, the search for alternative trade routes for Ukrainian goods quickly increased the demands on land and sea transport infrastructure and services. The work aims to identify trends in developing the main segments of the Ukrainian sea freight transportation market in current business conditions. To solve the tasks, the following methods were used: comparative analysis and grouping - in the study of general trends of the Ukrainian sea freight transportation market; systemic structural analysis - when studying the state and determining the prospects of tanker, container, and dry cargo transportation in Ukraine. An analysis of the general trends of the Ukrainian sea freight transport market was carried out. In addition, the state and prospects of tanker, container, and dry cargo transportation in Ukraine have been studied in detail. The tanker transportation sector was the most affected. Tanker transportation in Ukraine was suspended. Shipping companies engaged in the transportation of containers have stopped work in Ukrainian seaports. At the same time, a slight increase in the volume of container transportation was observed in the ports of countries bordering Ukraine. The complete blockade of Ukrainian seaports and the destruction and damage of infrastructure facilities made it impossible for dry cargo ships to reach Ukrainian ports. With Ukrainian seaports blocked and port operations suspended, grain exports from Ukraine were limited to shipments through western borders, rail, and small ports. The issue was partially resolved only within the framework of signing documents regarding the implementation of the Initiative on the safe transportation of agricultural products from three Ukrainian ports. The article outlines the critical factors in developing the maritime cargo transportation market in Ukraine during the post-war period of economic development.
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