Primary angiosarcoma of the breast is a rare malignancy with a poor prognosis, even after complete resection. Surgery is the mainstay of treatment with a limited role for chemotherapy and radiotherapy.
We present the case of a 55-year-old postmenopausal female who presented with complaints of a gradually increasing painless subareolar mass in the left breast of 4 months’ duration. Left-sided modified radical mastectomy was performed and the specimen was histopathologically diagnosed as invasive papillary carcinoma. Immunohistochemistry confirmed this diagnosis. All 8 excised axillary lymph nodes were negative for malignant cells. Postoperative chemotherapy was given and for the past 6 months, the patient has maintained a regular follow-up on an outpatient basis. She does not have any evidence of either local or distant recurrence of tumour metastases.
ACC is a rare malignant neoplasm. Surgical treatment is the mainstay with little role for radiotherapy and chemotherapy according to the published literature.
To study the clinical and histopathological features of medullary breast carcinoma (MBC) in rural population in Western Maharashtra. MATERIALS AND METHODS This is a retrospective, analytic study which is done at a tertiary care hospital from March 2010 to April 2016 for a period of 6 years. RESULTS Total of 241 consecutive cases of breast malignancy surgically operated for mastectomy or modified radical mastectomy were studied. From these 241 cases, 11 were reported as medullary carcinoma (constitute 4.56%). From these 11 cases, 10 cases were of typical medullary breast while 1 case was of atypical medullary breast carcinoma was noted. Each case was studied for clinical, morphological, radiological and immunohistochemistry (IHC) findings. For typical medullary carcinoma, the age range in present study was 33 to 55 years with a mean age of 46.3 years. The common clinical presentation was painless lump in the breast with common location being upper outer quadrant. The size of the tumour ranged from 2.5 to 9 cm with a mean size of 5.6 cm. The axillary lymph nodes were involved in 4 (40%) cases. The ER, PR and HER-2 were found to be positive in 10%, 10% and 20% respectively. Triple negative cases were 70%. CONCLUSION The clinicopathological features of medullary breast carcinoma showed early disease stage, having high-grade histological features of tumour, more triple negativity for ER/PR/HER2 and low rate of nodal metastasis.
Apocrine carcinoma is a very rare form of breast malignancy with an incidence of <1% of female invasive breast carcinoma. We report a case of apocrine carcinoma in a 42-year female with marked adenosis showing apocrine metaplasia and discuss the criteria to diagnose apocrine carcinoma with the emerging concept of androgen receptor positivity with its implication on treatment and management of the patient.
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