To study the clinical and histopathological features of medullary breast carcinoma (MBC) in rural population in Western Maharashtra. MATERIALS AND METHODS This is a retrospective, analytic study which is done at a tertiary care hospital from March 2010 to April 2016 for a period of 6 years. RESULTS Total of 241 consecutive cases of breast malignancy surgically operated for mastectomy or modified radical mastectomy were studied. From these 241 cases, 11 were reported as medullary carcinoma (constitute 4.56%). From these 11 cases, 10 cases were of typical medullary breast while 1 case was of atypical medullary breast carcinoma was noted. Each case was studied for clinical, morphological, radiological and immunohistochemistry (IHC) findings. For typical medullary carcinoma, the age range in present study was 33 to 55 years with a mean age of 46.3 years. The common clinical presentation was painless lump in the breast with common location being upper outer quadrant. The size of the tumour ranged from 2.5 to 9 cm with a mean size of 5.6 cm. The axillary lymph nodes were involved in 4 (40%) cases. The ER, PR and HER-2 were found to be positive in 10%, 10% and 20% respectively. Triple negative cases were 70%. CONCLUSION The clinicopathological features of medullary breast carcinoma showed early disease stage, having high-grade histological features of tumour, more triple negativity for ER/PR/HER2 and low rate of nodal metastasis.
Background: Breast cancer is one of the most common cancers worldwide in females and is an important cause of mortality and morbidity. FNAC is a safe, reliable, sensitive, specific, time saving and cost effective procedure useful in the diagnosis of carcinoma breast. It helps the surgeon in planning the treatment, and thereby reducing the delay in treatment. The primary aim of this study is to find out the spectrum of breast lesions on fine needle aspiration cytology based on IAC Yokohama system in a tertiary care hospital of north central Haryana.Methods: This is a retrospective study carried out in a tertiary care hospital of north-central Haryana and included 417 patients of palpable breast lumps presented in the Department of Pathology for FNAC during January 2018 to December 2019. FNAC was done under all aseptic conditions and various cytomorphological patterns were analysed according to the IAC Yokohama system for reporting breast fine needle aspirations.Result: Of the 417 cases included in the study, 328 cases were benign, 04 were atypical probably benign, 04 were suspicious for malignancy, 64 cases were malignant and 17 cases were inadequate for opinion. Fibroadenoma was found to be the most common breast lesion. Overall benign breast lesions are much more common than malignant lesions. Conclusion: FNAC is a useful tool to diagnose malignant lesions of the breast and help the surgeon in differentiating benign and malignant lesions. Early diagnosis aid in effective management of malignant lesions of the breast and thereby reducing the mortality in these patients.
INTRODUCTION Metaplastic carcinoma of the breast (MCB) denotes a heterogeneous group of rare malignant tumour of the breast expressing epithelial and/or mesenchymal tissue within the same tumour. AIMS To evaluate the clinicopathological features of 11 cases of metaplastic breast carcinoma in surgically excised malignant breast tumours in 8 years from April 2008 to March 2016. MATERIALS AND METHODS Total 284 consecutive cases of malignant breast lumps were removed surgically during study period, out of which 11 cases were diagnosed to have metaplastic breast carcinoma and were studied for its clinical features, size, site, gross morphological features, histopathological diagnosis, ER, PR, HER2 status, lymph node status. OBSERVATIONS Out of total 11 cases, 4 cases showed epithelial (tumour expressing adenocarcinoma and squamous cell carcinoma or squamous cell carcinoma alone), 6 cases showed biphasic (tumour expressing carcinoma and sarcomatoid or spindle cell component) and 1 case showed monophasic (tumour exclusively of sarcomatoid or spindle cell component). The mean age of the patient was 44 years, 8 cases were triple ER/PR/HER2 negative. Largest tumour size was 16 cm with mean size of 7 cm. Only 3 cases showed lymph node metastasis on histopathology. CONCLUSION In our study of metaplastic breast carcinoma, patients were found to be younger-mean age 44 years, as compared with other studies of metaplastic breast carcinomas. Clinically, they had bigger size of tumour-mean 7 cm, at presentation, aggressive course with low regional lymph node metastasis-27.3%. Most of these cases were triple negative (72.7%) for ER, PR and HER2 on immunohistochemical study.
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