Adenoid cystic carcinoma of female breast: A case report

Bhosale, Suresh; Kshirsagar, Ashok Y; Patil, Rahul Kalyanrao; Wader, Jyotsna; Nangare, Nitin; Patil, Pranita P.

doi:10.1016/j.ijscr.2013.01.025

Cited by 12 publications

(16 citation statements)

References 5 publications

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“…As one of the important methods for preoperative qualitative diagnosis of breast cancer, FNAC has a similar effect to pathological examination, and its diagnostic value has been generally recognized. However, for breast adenoid cystic carcinoma, only a few case reports or a small number of sample studies describe the application of FNAC in ACC diagnosis (6,(17)(18)(19)(20)(21)(22). The diagnostic cytological findings of ACC are rarely described.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnostic cytological findings of ACC are rarely described. There are only scattered descriptions, such as the cell smear having a single round circular hyperchromic cell, which exists in loose clusters, or the tumor cells surround the nucleus and sphere without cell homogeneous material (21,22), so there is no uniform conclusion on the diagnostic value of FNAC in ACC. Quinodoz et al (18) reported that immunocytochemistry may provide additional information on FNAC, which could be relevant not only for diagnosis but also for treatment and prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

et al. 2021

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ObjectiveThe purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.MethodsA total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed.ResultsFourteen patients were diagnosed with ACC of the breast, out of 23205 total patients treated for breast cancer (0.06%). All but three patients were postmenopausal, with a median age at diagnosis of 60.5 years (range, 39–73 years). The most common clinical presentation was a palpable mass (85.7%), and the imaging characteristics of all patients on color Doppler ultrasound and mammography were nonspecific. Six patients (42.9%) were suspected of having ACC by fine-needle aspiration cytology (FNAC) and were confirmed by postoperative histology and immunohistochemistry. All 14 patients underwent surgery, and no patient had a positive lymph node status. Median tumor size was 1.75 cm (range, 1–3 cm). Eight/14 (57.1%) patients were hormone receptor negative (HR−) and HER-2/neu (−) (HER2−). The remaining patients were hormone receptor positive (HR+). There was no significant difference in clinicopathological characteristics between the HR+ group and the HR- group (P>0.05). The mean follow-up period was 57 months. Local recurrence occurred in 14.3% of patients, 1.7% of patients had distant metastasis, all patients with local recurrence or distant metastasis were in the HR (-) group, and all patients were alive at the last follow-up.ConclusionACC of the breast cannot be simply summarized as triple-negative breast cancer because it also includes a small number of hormone receptor-positive breast cancers. Establishing a preoperative diagnosis is difficult on the basis of clinical imaging examination, FNAC may be useful tool in the diagnosis. the final diagnosis can only be assessed based on the results of the histopathological and immunohistochemical examination. Breast-conserving surgery may be an alternative treatment strategy, and axillary lymph node dissection or sentinel node biopsy may not be necessary in some cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

et al. 2021

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“…[1–4] Indeed, it is a epithelial tumor that usually originates in the salivary glands, submandibular glands, and minor salivary glands. [5,6] This tumor is malignant, has low local recurrence, and rarely leads to distant metastasis, [7,8] but is strictly location-dependent. Typically, it consists of small basaloid cells with a solid cribriform pattern or epithelial cells with a tubular growth pattern in histology.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma of the vagina

Zhang

Huang

et al. 2019

Medicine

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Rationale:Squamous carcinoma is the most common malignancy of vagina. Adenoid cystic carcinoma (ACC) in the vagina is very rare.Patient concerns:In the present study, we present a 45-year-old woman with a palpable swelling in the vagina. The patient reported body paresthesia, chest congestion, expiratory dyspnea, and itching in the thigh root.Diagnosis:The ultrasound results revealed inhomogeneous echoes of the muscular layer in the middle and distal of the vagina, and probed a slightly richer blood flow signal. Then biopsy was performed. On microscopic examination, it was observed that tumor cells were arranged in a tubular or cribriform pattern, and exhibited a consistent size, small nuclei, and nuclear fission. The myoepithelium was lined around the glandular cavity, but the myoepithelium was tumorous. Immunohistochemistry was performed for further verification. Vimentin was positive in mesenchyme and CK-P was positive in epithelial cells. P63 and calponin were spotted, which were focal positive around the glandular cavity. Finally, the patient was diagnosed as ACC.Interventions:At last, the patient chose chemoradiotherapy, not surgical excision.Outcomes:The patient is alive and well 13 months after the initial diagnosis.Lessons:ACC in the vagina is extremely rare. To our knowledge, this report is the first case of ACC arising from the vagina in English-language literature. Extensive surgical section of the tumour and chemoradiotherapy are recommended for therapy. Because of rarity, the prognosis of ACC in vagina is not known.

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“…Adenoid cystic carcinoma of the breast (ACCb) is a rare type of breast cancer, representing 0.1% of all breast tumours 2. Is more frequent in postmenopausal women with a typically triple negative phenotype (negative for oestrogen and progesterone receptors, and negative human epidermal growth factor receptor (HER2)),3 and has a histologically unique identity with biphasic pattern, consisting of laminate and pseudocystic spaces lined by myoepithelial cells, and glands lined by epithelial cells 4. This tumour has an indolent course and a good prognosis, with 5 years and 10 years overall survival of 94% and 86%, respectively,5 6 contrary to triple negative, ‘basal-like’ breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

et al. 2016

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Adenoid cystic carcinoma of the breast (ACCb) is a rare type of breast cancer. The treatment is not consensual. The authors report two cases of ACCb.Case 1: A 59-year-old woman with T1bN0M0, who went for lumpectomy and adjuvant radiation therapy (RT) (60 Gy in 30 fractions);Case 2: A 43-year-old woman, who went for modified radical mastectomy with T3N1M0, and underwent adjuvant chemotherapy, and a sequential regimen with antracyclin and taxane, prior to adjuvant RT (50 Gy/25 fractions).

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Adenoid cystic carcinoma of female breast: A case report

Abstract: ACC is a rare malignant neoplasm. Surgical treatment is the mainstay with little role for radiotherapy and chemotherapy according to the published literature.

Cited by 12 publications

References 5 publications

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study

Adenoid cystic carcinoma of the vagina

Adenoid cystic carcinoma: triple negative breast cancer with good prognosis

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