Background-Atypical nevi are a common risk factor for melanoma.

No author has a financial or proprietary interest in any material or method mentioned.

BACKGROUND Atypical nevi are a common risk factor for melanoma. OBJECTIVES The objective was to determine the utility of monitoring dermoscopic photographs of atypical nevi in a high‐risk population. METHODS Over a 4.5‐year period, digital dermoscopic photographs were taken of clinically atypical nevi at initial and follow‐up visits, such that side‐by‐side comparisons could be made. RESULTS A total of 5,945 lesions were monitored in 297 patients over 3 to 52 months (median, 22 months), and 324 lesions were biopsied. Photographic (dermoscopic) changes were noted in 96 of 5,945 (1.6%) lesions, which included 64 dysplastic nevi (67%), 25 common nevi (26%), and 1 melanoma (1.0%). Of 6 melanomas biopsied during the follow‐up period, only 1 was detected by dermoscopic photographic change at follow‐up. CONCLUSIONS Most clinically atypical melanocytic nevi are stable over time, and lesions exhibiting dermoscopic changes are most likely to be dysplastic nevi. Although dermoscopy is a useful tool for clinical examination, the sensitivity of dermoscopic monitoring is limited by melanomas that may arise in normal skin or in clinically benign nevi that were not initially photographed.

In this rabbit study, the new hydrophobic acrylic material was biocompatible. The barrier step incorporated to the optic-haptic junctions has the potential to enhance PCO prevention.

The new IOL has large optic and overall diameters, smooth and undulating haptics, and a convex-concave optic profile. Results show that these characteristics minimize the possibility of interaction with the primary IOL and uveal tissues, decreasing the likelihood of optical aberrations and pigmentary dispersion.

If the drug-delivery system gains access to the anterior chamber, it may cause substantial corneal edema and inflammation, even at low doses and after topical administration.

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