Persalinan adalah proses alami dan menimbulkan nyeri, namun banyak ibu yang tidak bisa menahan rasa nyeri tersebut karena dipengaruhi oleh stres. Terapi non farmakologi yang dapat digunakan untuk mengurangi rasa nyeri adalah Murotal Al-Qur'an. Terapi ini dapat menstimulasi gelombang delta yang menyebabkan pendengar dalam keadaan tenang, tentram dan nyaman sehingga hypopfise dan hypothalamus mengeluarkan β-Endorphin sebagai analgesik alamiah. Tujuan penelitian ini membuktikan bahwa terapi murotal Al-Qur'an Surat Ar-rahman dapat meningkatkan kadar β-Endorphin dan menurunkan intensitas nyeri persalinan pada kala I fase aktif. Penelitian ini dilakukan di rumah sakit Abunawas Kendari dan Laboratorium Fakultas Kedokteran UNHAS. Desain penelitian Quasi-Experimental dengan pendekatan Pre-Experimental design One-Group Pre-test-Post-test. Pengambilan sampeldengan tehnik purposive sampling sebanyak 30 orang. Pengukuran kadar β-Endorphin dilakukan dengan ELISA kit dan intensitas nyeri persalinan diukur dengan menggunakan Bourbannis pain scale. Analisis data dengan Kolmogorov-Smirnov dan uji t berpasangan. Hasil penelitian menunjukkan ada penurunan signifikan intensitas nyeri sebelum (6,80±1,52) dibandingkan sesudah (3,37±1,79) pemberian terapi murotal Al-Qur,an surat Ar-rahman selama 25 menit (p=0,000). Terapi murotal Al-Qur'an juga menunjukkan peningkatan signifikan (p=0,000) kadar β-Endorphin sebelum perlakuan (1053,6±606,32ng/L) dan setelah perlakuan (1813,6±546,78ng/L). Dapat disimpulkan bahwa pemberian terapi murotal Al-Qur'an dapat menurunkan intensitas nyeri dan meningkatkan kadar β-Endorphin.

Dengue is a viral disease, transmitted by Aedes aegypti, and is still a big problem in tropical areas, including Indonesia, where the temperatures are relatively warm and suitable for vector mosquito life. In the dry season, the day and night temperature differences are quite sharp and, at that time, the number of dengue cases is low. In this study, the difference between day and night temperature is referred to as daily temperature fluctuation and represented by the maximum and minimum temperature difference in each month. The research was conducted in Sleman Regency, Yogyakarta Province, Indonesia, as an endemic area, and the data were collected from 4 endemic areas in Sleman; Gamping, Godean, Sleman, and Depok districts. The data collected were quantitative with serial data retrospective. Secondary data of monthly dengue incidence in the years 2008 - 2013 were obtained from the Regency Health Office and used as a dependent variable. Monthly minimum and maximum temperatures in the same periods were obtained from the Agency of Meteorology, Climatology, and Geophysics. The differences between the minimum and maximum temperatures were calculated, to be used as independent variable data, and represented the different day and night temperatures of the month. Data were analyzed by using linear regressions to determine the influence of fluctuating temperature on the incidence of dengue. Results show that fluctuating temperature affected dengue incidence in the districts of Godean (p = 0.000; R2 = 0.207) and Gamping (p = 0.006; R2 = 0.125), but did not affect it in Sleman (p = 0.164) or Depok (p = 0.075). The data suggests that fluctuating temperature affected dengue incidence with powers of 20.7 % in Godean and 12.5 % in Gamping.

Domestic violence also called "domestic abuse" or "intimate partner violence", can be defined as a pattern of behavior in any relationship that is used to gain or maintain power and control over an intimate partner. Abuse is physical, sexual, emotional, economic, or psychological actions or threats of actions that influence another person. This includes any behaviors that frighten, intimidate, terrorize, manipulate, hurt, humiliate, blame, injure, or wound someone. Furthermore, it is common among women, which globally increases the risk of pregnancy. This research aimed to analyze the trigger factors of domestic violence among pregnant women. The interviews with eight participants were analyzed using the Colaizzi method. It produced five main themes, namely, the husband is often angry and fight since having an affair, income is not sufficient to fulfill the monthly needs, fights because the husband feels jealous, the husband is temperament, smacks, and also berates when drunk, fights because husband spends money on gambling.

This study aimed to analyze the effect of 'Sintanur' brown rice on Lee's index, fasting blood glucose levels, and HOMA-IR administered to male Sprague Dawley rats. This research was an experimental laboratory study with a post-test-only control group design. The subjects were thirty-five male Sprague Dawley rats divided into five groups. Group 1 consisted of the negative control with a standard diet. Group 2 consisted of the positive control with HFFD-induced obesity for 20 weeks, while groups 3, 4, and 5 were the treatment groups with HFFD-induced obesity for 12 weeks, which were intervened with different dosages of brown rice diet from week 13 to week 20. At week 21, the rats were sacrificed. Fasting blood glucose levels were tested using a glucometer. Fasting serum insulin levels were tested using ELISA. HOMA-IR was calculated using fasting glucose and insulin levels. Serum magnesium levels were tested using Atomic Absorption Spectrophotometry. A non-parametric test of Kruskal-Wallis was used to analyze differences in mean dietary intake, Lee index, fasting blood glucose, and HOMA-IR. As a result, there were significant differences between groups (p<0.05). Spearman correlation test was used to analyze the relationship between the Lee index, fasting blood glucose levels, and HOMA-IR with serum magnesium levels. As a result, there were negative correlations between parameters (r=-0.299; r=-0.393; r=-0.257). Group 5 had the best results in lowering insulin resistance. In conclusion, consuming local 'Sintanur' brown rice decreased the Lee index, fasting blood glucose levels, and HOMA-IR by increasing serum magnesium levels in obese rats. High magnesium intake reduces insulin resistance by correcting the disruption of glucose metabolism and insulin signaling pathways.

The theory of planned behavior states that intention is the best predictor of behavior. The intention to perform a behavior is determined by a person's attitude, subjective norms, and perceived behavioral control. As volunteers in the health sector, volunteers of the Indonesian Red Cross (PMI) have been equipped with knowledge and skills regarding the role of an OHCA bystander. Besides, the intentions of PMI volunteers greatly affect a person's tendency to be willing or unwilling to become an OHCA bystander. This study aims to apply the theory of planned behavior in identifying the factors that influence the intentions of PMI volunteers in acting as OHCA bystanders and the dominant factors that affect intentions. This study used an observational research type with a cross-sectional approach. The respondents in this study were 105 PMI volunteer members in Tuban Regency, which were conducted using the purposive sampling technique. In determining the most dominant factor that influenced intention, ordinal logistic regression analysis was used in which it was shown that the variable used in the last modeling analysis stage was the subjective norm (OR= 6.19). Based on the results of the analysis, it can be concluded that subjective norms are the most predictor factor that influences intentions.

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BackgroundIncreased understanding in molecular pathology of advanced non-small cell lung cancer (NSCLC) over the past decades has led to personalized treatment approaches being advocated. Epidermal growth factor receptor (EGFR) mutation that often occurs in NSCLC can be identified using immunohistochemical examinations. Moreover, clarifying the relationship between computed tomography (CT) and EGFR mutation of NSCLC might inform therapeutic decision-making. The purpose of this study was to determine the relationship between metastatic sites on primary chest CT-scan and EGFR mutation in NSCLC lung cancer patients. MethodsAn cross-sectional design using secondary data was conducted, involving 76 NSCLC patients. EGFR mutations were determined by immunohistochemical examination and metastatic sites by chest CT-scan with contrast. The collected metastatic sites comprised hilar and mediastinal lymphadenopathy, pulmonary nodules, and bone, liver, spleen and suprarenal metastases. A Chi square test was used to analyze the data. ResultsThis study revealed that the highest NSCLC stage was IVb, found in 39 samples (51.3%), while 34 (44.7%) subjects had EGFR mutation. There was no statistically significant difference between metastatic site and positive EGFR mutation, although positive bone metastases (54.8%) tend to have more numerous positive EGFR mutations compared to negative bone metastases (37.7%) (p=0.142). ConclusionsPatients with positive bone metastases tend to have higher positive EGFR mutation compared to negative bone metastases in NSCLC lung cancer patients. Prospective studies evaluating patients with EGFR mutation for bone metastases should be considered. This can provide information on therapeutic decision-making to obtain good clinical outcomes.

<p>Kehamilan pertama bagi seorang ibu merupakan periode krisis dalam kehidupannya. Kecemasan dapat muncul karena masa panjang menanti kelahiran dan ketidakpercayaan diri Ibu merawat bayinya. Oleh karena itu, primigravida membutuhkan informasi yang memadai tentang persiapan persalinan. Kombinasi diskusi kelompok kecil dan pemodelan merupakan metode pembelajaran yang bermanfaat dalam meningkatkan derajat kesehatan ibu, salah satunya dengan menurunkan kecemasan dalam menghadapi persalinan. Penelitian ini bertujuan membuktikan pengaruh penerapan kombinasi metode diskusi kelompok kecil dan pemodelan terhadap kecemasan primigravida dalam menghadapi persalinan. Desain penelitian adalah true eksperimen dengan rancangan randomized subject, pretest-posttest control group design. Penelitian dilakukan di Puskesmas Poka Rumah Tiga Kota Ambon. Sampel dalam penelitian ini sebanyak 24 responden yang dibagi 2 kelompok yaitu kelompok intervensi dan kontrol. Pengukuran kecemasan primigravida menghadapi persalinan menggunakan Hamilton Anxiety Rating Scale (HARS). Data dianalisis dengan uji paired t-test dan independent t-test dengan α=0,05. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan kecemasan primigravida menghadapi persalinan sebelum dan setelah penerapan kombinasi metode diskusi kelompok kecil dan pemodelan serta antara kelompok intervensi dan kelompok kontrol (p=0,000). Dapat disimpulkan bahwa penerapan kombinasi metode diskusi kelompok kecil dan pemodelan dapat menurunkan kecemasan primigravida dalam menghadapi persalinan.</p>