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Context: Several species of the genus Annona were reported to have hypoglycemic properties and this makes Annona reticulata Linn. (Annonaceae) an interesting plant for investigating its anti-hyperglycemic potential.Objective: Different fractions prepared from hydro-alcoholic extract of A. reticulata leave were investigated for their blood glucose lowering effect on Streptozotocin (STZ) induced hyperglycemic rats.Methods: Ethyl acetate, methanol, and residual fractions (at dose level of 100 mg/kg by oral route) prepared from the hydro-alcoholic extract of A. reticulata leave were administered for 14 consecutive days to STZ induced hyperglycemic rats for evaluation of their anti-hyperglycemic potential. Anti-hyperglycemic potential was assessed by observation of a decrease in fasting blood glucose level. Results:The studies revealed that ethyl acetate fraction decreased the blood glucose level of hyperglycemic rats from 447.67 to 234.17 mg/dL and is significant (p<0.001) when compared with diabetic control group. The residual fraction and methanolic fraction decreased blood glucose level from 417.83 to 402.50 mg/dL and 432.33 to 371.67 mg/dL respectively but not significant when compared with the diabetic control group. Standard drug metformin (dose 300 mg/kg) reduced the blood glucose level from 447.33 to 219.50 mg/dL. Discussion: Ethyl acetate fraction at tested dose level was capable not only to control the elevated blood glucose level but also able to attenuate certain secondary parameters associated with STZ induced hyperglycemia. Conclusion:This study suggested that the ethyl acetate fraction prepared from hydro-alcoholic extract of A. reticulata leave exhibit potential antihyperglycemic property in the tested experimental models and should be investigated further.

The study found no evidence that paracetamol usage either as prophylactic or for treatment impact immunological responses to DTwP-HepB-Hib combination vaccine. [Clinical trial registry of India (study registration number CTRI/2012/08/002872)].

GC-MS analysis of fractions prepared from hydro-alcoholic extract of Annona reticulata Linn (Family Annonaceae) leaf revealed the presence of 9,10-dimethyltricyclo[4.2.1.1(2,5)]decane-9,10-diol; 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one; 3,7-dimethyl-6-nonen-1-ol acetate; 9-octadecenamide,(Z)-; glycerine; D-glucose,6-O-α-D-galactopyranosyl-; desulphosinigrin and α-methyl-D-mannopyranoside as few of the major compounds in different fractions. The presence of these compounds in the plant has been identified for the first time.

Introduction: Kidney transplantation (KTx) is one of the treatment choices for individuals with end-stage renal failure. Severe deceased donor organ shortage and long waiting times on the deceased donor list remains a worldwide serious problem, that requires us to refer to living donors. In order not to harm the donors, the criteria for selecting living donors must be strict in order to ensure the safety of the donors on the one hand and optimize the results for the recipients on the other hand the purpose of our work is to determine the epidemiological profile of the challenged donors, and to identify the medical causes of exclusion. Methods: it is a single center retrospective descriptive and analytical study, on 43 donors rejected of kidney donation over a period of 7 years between 2011 and 2018, conducted in the nephrology department of Casablanca. The parameters analyzed are: age, sex, relationship between donor and recipient, medical causes of refusal. Results: These are 43 recused donors, the average age is 43.9 years (23 to 66 years), of which 58.3% are women and 41.7% are men. and BMI 25.7 +/-3.8 kg/m2, the applicants for the donation were from ascendants, collaterals and spouses with a rate of 44.4%, 36.1% and 19.5% respectively. The causes of donor exclusion were: the presence of donor-specific anti-HLA antibodies in the luminex recipient with a Median Fluorescence Intensity of 4767 (three cases), positive cross-match (one case), age limit (four cases), hypertension (three cases), diabetes (five cases), obesity (five cases), disrupted kidney status: renal failure (one case), proteinuria (one case), microscopic hematuria (two cases), morphological abnormality: renal microlithiasis (three cases), renal cysts (four cases), vascular abnormalities (six cases), pulmonary sarcoidosis (one case), myelodysplasia (one case), psychosocial causes in two cases (table 1)