Sat-338 the Dilemma of Induction Immunosuppression in Low Immunological Risk Kidney Transplant Recipients- A Prospective Randomised Study From Eastern India Comparing Basiliximab Versus No Induction Immunosuppression

Abstract

Introduction: Kidney transplantation (KTx) is one of the treatment choices for individuals with end-stage renal failure. Severe deceased donor organ shortage and long waiting times on the deceased donor list remains a worldwide serious problem, that requires us to refer to living donors. In order not to harm the donors, the criteria for selecting living donors must be strict in order to ensure the safety of the donors on the one hand and optimize the results for the recipients on the other hand the purpose of our work is to determine the epidemiological profile of the challenged donors, and to identify the medical causes of exclusion. Methods: it is a single center retrospective descriptive and analytical study, on 43 donors rejected of kidney donation over a period of 7 years between 2011 and 2018, conducted in the nephrology department of Casablanca. The parameters analyzed are: age, sex, relationship between donor and recipient, medical causes of refusal. Results: These are 43 recused donors, the average age is 43.9 years (23 to 66 years), of which 58.3% are women and 41.7% are men. and BMI 25.7 +/-3.8 kg/m2, the applicants for the donation were from ascendants, collaterals and spouses with a rate of 44.4%, 36.1% and 19.5% respectively. The causes of donor exclusion were: the presence of donor-specific anti-HLA antibodies in the luminex recipient with a Median Fluorescence Intensity of 4767 (three cases), positive cross-match (one case), age limit (four cases), hypertension (three cases), diabetes (five cases), obesity (five cases), disrupted kidney status: renal failure (one case), proteinuria (one case), microscopic hematuria (two cases), morphological abnormality: renal microlithiasis (three cases), renal cysts (four cases), vascular abnormalities (six cases), pulmonary sarcoidosis (one case), myelodysplasia (one case), psychosocial causes in two cases (table 1)