Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves

Jain, Anju; Soni, Monika; Deb, Lokesh; Jain, Anurekha; Rout, Soumya P.; Gupta, Vishnu Dev; Krishna, K L

doi:10.1016/j.jep.2007.09.009

Cited by 189 publications

(132 citation statements)

References 18 publications

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“…Natural products have long been an important source of therapeutic agents for this purpose (Asha et al, 2007;Jain et al, 2008), and R. offi cinalis is well known for its antioxidant properties (Amin and Hamza, 2005;Rusu et al, 2005). Our studies using an experimental cirrhosis model have confi rmed these properties and provided evidence for the traditional use of R. offi cinalis as a hepatoprotective agent.…”

Section: Resultssupporting

confidence: 64%

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Gutiérrez

Alvarado

Presno

et al. 2009

Phytotherapy Research

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Rosmarinus offi cinalis (Lamiaceae) possesses antioxidant activity and hepatoprotective effects, and so may provide a possible therapeutic alternative for chronic liver disease. The effect produced by a methanolic extract of Rosmarinus offi cinalis on CCl 4 -induced liver cirrhosis in rats was investigated using both prevention and reversion models. Over the course of the development of cirrhosis, the increased enzymatic activities of gammaglutamyl transpeptidase and alanine aminotransferase, and the rise in bilirubin levels caused by CCl 4 administration, were prevented by Rosmarinus offi cinalis co-administration. When the cirrhosis by oxidative stress was evaluated as an increase on liver lipoperoxidation, total lipid peroxides, nitric oxide in serum, and loss of erythrocyte plasma membrane stability, R. offi cinalis was shown to prevent such alterations. On cirrhotic animals treated with CCl 4 , histological studies showed massive necrosis, periportal infl ammation and fi brosis which were modifi ed by R. offi cinalis. These benefi ts on experimental cirrhosis suggest a potential therapeutic use for R. offi cinalis as an alternative for liver cirrhosis.

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Section: Resultssupporting

confidence: 64%

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Gutiérrez

Alvarado

Presno

et al. 2009

Phytotherapy Research

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“…Literature survey reveals that the most antioxidant activities from plant sources are correlated with phenolic compounds 12,13 . Total flavonoids varied from 24.20 to 92.50 mg QE/g.…”

Section: Total Phenolics and Flavonoids Contentsmentioning

confidence: 99%

Evaluation of antimicrobial and antioxidant activities of solvent extracts of Anacyclus pyrethrum L., from Algeria

et al. 2012

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Abstract:In the present study, solvent extracts from aerial parts of Anacyclus pyrethrum L. were assessed for their total phenol content, antimicrobial and antioxidant (1,1-diphenyl-2-picrylhydrazyl free radical scavenging and ferric-ion reducing power) activities. The amounts of total phenolics and flavonoids in the solvent extracts were determined spectrometrically. (310.78 mg GA/g extract) and antioxidant activity (IC 50 = 0.056 mg/mL).Increasing the concentration of the extracts resulted in increased ferric reducing antioxidant power for both extracts tested.The methanolic extract exhibited the best antimicrobial activity against three gram-positive bacterium (Listeria monocytogenes: 100%, Bacillus. cereus: 69% and Staphylococcus aureus: 66%), as well as against Candida albicans (81%).Finally, a relationship was observed between the biological activities potential and total phenolic and flavonoid levels of the extract. The results of this study provided an alternative of utilising Anacyclus pyrethrum aerial parts as readily accessible source of natural antioxidant in food cosmetic and pharmaceutical industry.

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“…The CCl 4 -induced experimental damage resembles viral hepatitis histologically due to the formation of free radicals and the occurrence of lipid peroxidation in cellular and organelle membranes (Wu et al, 2007). Toxicity begins with a highly reactive trichloromethyl free radical (·CCl 3 ), which is further converted to trichloromethyl peroxyl radical (CCl 3 OO·), a classical form of reactive oxygen species (ROS), as the initiator of lipid peroxidation (Hsiao et al, 2003;Jain et al, 2008;Ranawat et al, 2010). That is, excessive production of free radicals accelerates the peroxidative degradation of cellular membrane, leading to the breakdown of cell integrity and the leakages of ALT and AST.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Gao

Sun

Yang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl 4 )-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl 4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

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Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves

Cited by 189 publications

References 18 publications

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Evaluation of antimicrobial and antioxidant activities of solvent extracts of Anacyclus pyrethrum L., from Algeria

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

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Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves

Cited by 189 publications

References 18 publications

Oxidative stress modulation by Rosmarinus officinalis in CCl4‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl4‐induced liver cirrhosis

Evaluation of antimicrobial and antioxidant activities of solvent extracts of Anacyclus pyrethrum L., from Algeria

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

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Product

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Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis