Context: Lycopene, a carotenoid found in tomatoes, possesses antiangiogenic activities that might be useful in the management of prostate enlargement. However, the current evidence is still inconclusive in regard to this matter. Aims: The aim of the study was to investigate the effect of combined oral dutasteride and lycopene consumption in reducing posttransurethral resection of the prostate (TURP) bleeding. Settings and Design: Twenty-two individuals diagnosed with benign prostatic hyperplasia were randomly allocated into two groups of equal size. Thirty days prior to TURP, individuals in Group 1 (control) were given daily oral dutasteride 0.5 mg and placebo pill and individuals in Group 2 (intervention) were given dutasteride 0.5 mg and lycopene 30 mg. Subjects and Methods: The parameters measured in this study were pre- and post-TURP plasma erythrocyte count and microvessel density (MVD) of resected prostate tissue stained with CD34. Statistical Analysis Used: Data homogeneity was tested using the Shapiro–Wilk test. Individuals' characteristics were analyzed using the Mann–Whitney U-test and plasma erythrocyte and MVD analyzed using the t-test. Spearman's correlation analysis was performed to find significant correlations between the two variables. Results: There were two dropouts. The mean MVD in the control group was significantly higher compared to the intervention group (28.2 ± 12.3 vs. 18.3 ± 7.6 vessel/mm2, P = 0.044). Reduction of post-TURP plasma erythrocytes was significantly higher in the control group compared to the intervention group (−0.34 ± 0.18 vs. −0.17 ± 0.12 106/μL, P = 0.048). Conclusions: Daily consumption of dutasteride and lycopene for at least 30 days reduced the formation of blood vessels in the prostate and reduced blood loss post-TURP.
ABSTRAK Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum ABSTRACT Ovarian endometriosis is associated with an increased risk of ovarian epithelial carcinoma (RR 1.9-4.2). Endometrioid carcinoma is one of the most common type of malignancy associated with endometriosis, while serous carcinoma is the most common ovarian cancer type. It has been reported that sera pro-inflammatory interleukin-1 (IL-1) β evidently be involved in both endometriosis (p = 0,034 and p=0,020), while group B vs group C was not significant (p = 0,805). There are some differences in IL-1β expression among ovarian endometriosis, endometrioid carcinoma, and serosum carcinoma, but there are no significantly difference between ovarian endometrioid carcinoma and serosum carcinoma.
Background: Glycogen rich clear cell carcinoma is a rare neoplasm of the breast, with the incidence of 1.4-3% of all breast cancers. The tumour has distinct morphology, different from that of common breast cancers. Glycogen rich clear cell carcinomas are members of a heterogeneous group of neoplasms, including signet-ring, secretory and lipid-rich carcinomas of the breast. In general, clear cell breast carcinoma tends to follow an aggressive clinical course. Case report: To present a case of a 47 years old woman suffering from breast mass in the upper outer quadrant of her right breast. On macroscopic examination, the biopsy tumor sized 2x1.5x0.5 cm and solid with brown and white. Discussion: Microscopic examination showed breast tissue composed of tumor cells arranged in nets, trabeculae and singly dispersed. Tumor cells are moderately pleomorphic, have sharply defined border and polygonal contours. Cytoplasm is clear in more than 90% of cells and finely granular in few cells. Nuclei are hyperchromatic with clumped chromatin and prominent nucleoli. Occasional mitosis is also observed. Special stain (PAS Staining): Intracytoplasmic PAS positivity in tumor cells are variable. Immunohistochemistry ER (+) positive >20-50%, PR (+) positive <20%, HER2 (-) negative. The patient was diagnosed with glycogen rich clear cell carcinoma. Conclusion: Glycogen rich clear cell carcinoma of the breast is rare. Its clinical feature is rather aggressive and varies depending on special characteristics such as low grade. Keywords: Glycogen rich clear cell carcinoma, breast carcinoma, PAS staining Latar belakang: Glycogen rich clear cell carcinoma adalah kanker payudara yang jarang, dengan insidensi 1.4-3% dari semua kanker payudara. Tumor memiliki morfologi yang berbeda dari kanker payudara pada umunya. Glycogen rich clear cell carcinoma merupakan neoplasma heterogen yang termasuk karsinoma payudara signet-ring, sekretori dan kaya lipid. Secara umum, carcinoma ini cenderung mengikuti perjalanan klinis yang agresif. Tujuan: Laporan Kasus: Dilakukan pemeriksaan makroskopis jaringan tumor dari seorang perempuan berusia 47 tahun dengan massa payudara kanan di kuadran luar atas. Tumor biopsi berukuran 2x1.5x0.5 cm, komposisi padat, berwarna coklat dan putih. Dilakukan pemeriksaan histopatologi, imunohistokimia dan histokimia pewarnaan khusus PAS (Periodic Acid Schiff). Pembahasan: Pemeriksaan mikroskopis menunjukkan jaringan payudara dengan sel-sel tumor yang tersusun dalam jaring, trabekula dan tersebar tunggal. Sel-sel tumor cukup pleomorfik, hiperkromatik, kromatin kasar dan nucleoli prominent, mitosis dapat ditemukan, sitoplasma jernih lebih dari 90% sel dan granular halus dalam beberapa sel, memiliki garis batas dan beberapa bentuk poligon yang jelas. Hasil histokimia PAS (+) positif, Immunohistokimia ER (+) positif > 20-50% pada sel-sel tumor, PR (+) positif < 20%, HER2 (-) negatif. Dari hasil pemeriksaan tersebut, pasien didiagnosis Glycogen rich clear cell carcinoma. Kesimpulan: Glycogen rich clear cell carcinoma pada payudara adalah tumor yang jarang, perilaku klinisnya dilaporkan agak agresif sejauh ini, sangat bervariasi tergantung pada karakteristik khusus seperti tingkat rendah. Kata kunci: Glycogen rich clear cell carcinoma, karsinoma payudara, pewarnaan PAS.
Invasive carcinoma of no special type adalah tipe karsinoma invasif payudara yang paling umum (40% - 75%). Angiogenesis pada tumor merupakan faktor prognostik pada kanker payudara karena berpengaruh pada faktor pertumbuhan, invasi dan metastasis tumor. Neovaskularisasi dideteksi dengan ekspresi Vascular Endothelial Growth Factor (VEGF) dan Endoglin. Desain analitik observasional dilakukan dengan pendekatan cross-sectional. Populasi dan sampel adalah blok parafin yang secara histopatologis telah didiagnosis sebagai Invasive carcinoma of no special type derajat 1, 2 dan 3 serta klasifikasi molekuler Luminal A, Luminal B, Her-2 (+) dan triple-negative di laboratorium Patologi Anatomi RSUP dr. Kariadi Semarang. Sampel diproses dengan metode pewarnaan VEGF dan Endoglin. Ekspresi VEGF diberi skor semi-kuantitatif menjadi 0-2 (negatif), 3-4 (positif), 5-6 (positif kuat). Ekspresi endoglin dinilai positif jika diamati sebagai endapan linear tipis di membran dan sitoplasma sel endotel di pembuluh mikro. Kerapatan microvessel adalah median microvessel yang diwarnai secara positif oleh Endoglin di 5 lapangan pandang besar. Korelasi antar variabel dianalisis dengan uji korelasi Spearman.Terdapat korelasi sedang antara ekspresi VEGF dengan klasifikasi molekuler (p = 0,042 (p < 0,05), r = 0,373. Terdapat korelasi, tapi tidak bermakna antara ekspresi VEGF dengan derajat histopatologik (p = 0,749 ( p > 0,05), r = - 0,061), ekspresi Endoglin dengan klasifikasi molekuler (p = 0,543 (p > 0,05), r = 0,116), ekspresi Endoglin dengan derajat histopatogik (p = 0,965 (p > 0,05), r = - 0,008). VEGF dan Endoglin memiliki peran sebagai faktor prognostik pada Invasive breast carcinoma of no special type.
Trans Urethral Resection of the Prostate (TURP) is one of the gold operating standards for people with Benign Prostate Hyperplasia (BPH), but the complications, like bleedings, often occur both in durante and post-surgery. The risk of bleeding in TURP is caused by angiogenesis. Hypoxia-Induced Factor-1 Alpha (HIF-1 α) is one of the trigger factors for angiogenesis in BPH. Based on the existing literature, it was found that there was a relationship between lycopene and dutasteride which both had a synergistic effect in inhibiting angiogenesis. However, the mechanism is unknown. This study aims to assess the effectiveness of the combination of dutasteride and lycopene on the expression of HIF-1α and hematocrit levels in BPH patients undergoing TURP surgery. This research was an experimental study with "Double-Blind Randomized Controlled Trial Post Test Only Design". The 22 patients were divided into 2 groups, namely T (dutasteride + lycopene), C (lycopene+plasebo), which were given every 24 hours for a minimum of 30 days until the TURP operation was carried out. The observation of HIF-1α expression used immunohistochemical methods. Different tests were conducted between the groups with Independent T-test. The result shows the combination of dutasteride and lycopene was not significant in reducing the HIF-1α expression, indicated by mean rank in the group (C) (= 21.60), group (T) (= 20.00). The results obtained from the Independent T-test were (p = 0.410), meaning the difference in HIF-1α expression between the 2 groups was not significant: Average Δ Ht group C (= 1.26); group T (= -0,98). The statistical test with the Independent T-test obtained (p = 0.027), where there were significant differences. Giving a combination of dutasteride and lycopene for at least 30 days pre-TURP surgery was not effective in reducing the expression of hypoxia-induced factor - 1 alpha (HIF-1α) but was effective in reducing hematocrit levels compared to a single administration of dutasteride in BPH patients undergoing TURP surgery.
Introduction: Gastrointestinal stromal tumor (GIST) is a rare neoplasm representing 80% of gastrointestinal neoplasms. Laparoscopic resection is only recommended for GIST less than 2 cm and 5 cm for laparoscopic wedge resection. Thus, a large GIST is recommended to complete resection through laparotomy. A large GIST of the gastric fundus can be found in patients, which coincides with an upper right abdominal quadrant pain caused by cholecystolithiasis. A suggested laparotomy for tumor resection and cholecystectomy may result in poor recovery in the postoperative period. Therefore, one approach surgery with minimally invasive laparoscopic partial gastrectomy using Endoflex stapler and cholecystectomy was performed to achieve the optimal outcome.Case Presentation: A 43-year-old male had a major complaint of hematemesis and melena for one month and colicky pain in the right upper quadrant of the abdomen with increased intensity in the last two months. Contrast-enhanced abdominal MSCT revealed a solid 4.6 x 4 x 5.6 cm exophytic mass on the gastric fundus, added with 0.5 cm gall bladder stone. Laparoscopic partial gastrectomy and cholecystectomy were performed in a single minimal invasive surgical procedure. The post-operative period was uneventful. The patient experienced minimum pain, early mobilization, and better diet tolerance. He was discharged on day four after the surgery. Besides, the histopathologic result revealed a malignant mesenchymal tumor according to GIST with a tumor-free margin of resection.Conclusions: Single approach surgery with minimal laparoscopic partial gastrectomy and cholecystectomy has provided optimal outcomes for patients with large GIST and cholecystolithiasis.
Triple negative breast cancer (TNBC) merupakan jenis karsinoma payudara yang agresif dan prognosis yang buruk. MMP-9 memiliki kemampuan mendegradasi membran basal sehiungga berhubungan dengan invasi sel tumor dan metastasis kelenjar getah bening (KGB). Penelitian ini bertujuan untuk membuktikan hubungan antara ekspresi MMP-9 dengan usia pasien dan metastasis ke kelenjar getah bening. Jenis penelitian ini adalah cross sectional, menggunakan 29 sampel blok parafin tumor primer pasien. Sampel dipulas dengan pengecatan imunohistokimia MMP-9 dinilai dengan menggunakan metode Allred (Ekspresi rendah=0-3; tinggi >4). Karakteristik klinikopatologi didapatkan dari rekam medis atau arsip patologi. Uji hipotesis menggunakan uji Fisher-Exact. Korelasi antara ekspresi MMP-9 dengan metastasis dinilai dengan korelasi Pearson untuk data nominal. Hasil penelitian diperoleh umur subyek penelitian adalah 49,8±9,67 (32-73) tahun. Usia >40 tahun 22 subyek (75,9%.) Kejadian metastasis KGB 75,9%. Ekspresi MMP-9 tinggi sebanyak 23 subyek (79,3%). Hubungan antara kategori usia >40 tahun dengan kejadian metastasis tidak bermakna (p=0,6). Hubungan antara kategori usia >40 tahun dengan ekspresi MMP-9 tinggi tidak bermakna (p=0,6). Hubungan antara kejadian metastasis dengan ekspresi MMP-9 tinggi adalah bermakna (p<0,001; koefisien korelasi=0,8 (95% IK= 0,5 s/d 1,0), rasio prevalensi 5,7 (95% IK= 1,0 s/d 34,4). Hubungan antara ekspresi MMP-9 dengan metastasis KGB yang bermakna dijumpai pada usia £40 tahun (p=0,01) dan usia >40 tahun (p=0,04). Kesimpulan penelitian ini adalah ekspresi MMP-9 yang tinggi berhubungan dengan metastasis ke kelenjar getah bening pada TNBC.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.