SUMMARYWithin a prospective study of 56,109 total births, 457 youngsters have been found to have congenital heart disease. The overall incidence is 8.14/1000 total births, 8.0/1000 for the Negro and 8.3/1000 for the white. A Spontaneous closure racardiac malformations Racial relative rarity of congenital cardiac defects, and the natural history of many of these lesions, it is also not surprising that in previous studies various truncations have occurred, i.e., absence of specific lesion diagnosis, data restricted to autopsied patients, or experience limited to a single hospital. This study, while having some limitations, provides rates by specific lesion for total births (stillbirths and live births) among 56,109 whites and blacks at

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A new virus, provisionally named Herpesvirus vitreum, was isolated from hyperplastic epidermal tissue from a walleye, Stizostedion vitreum vitreum (Mitchill), taken in Saskatchewan, Canada. The virus, which was isolated in the walleye ovarian (WO) cell line, was identified as a herpesvirus on the basis of size (190-230 nm), morphology and apparent pattern of replication. The virus, which passes polycarbonate membranes of 200 nm mean pore diameter, was ether-labile. Virus replicated in WC-1 cells at 4 and 15X, but not at 20 C. Although walleye cell lines (WO, WC-1, We-2) were susceptible to infection at 15 C, non-percid cell lines were refractory. Syncytial formation and lysis occurred in susceptible cell lines. Virus was quantified by plaque assay at 13 to 15 C for two weeks. Replication was inhibited by IO'^-'^M phosphonoacetate and by lO"^-*^ M 5-bromodeoxyuridine (BUDR), but addition of excess thymidine reversed the inhibition by BUDR. Viral replication in WO cells, but not in WC-1 cells, was inhibited by the antiherpetic drug acyclovir (10"^-" M). The relationship of the herpesvirus isolate and epithelial neoplasms was not determined.

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