Etiologic correlates in a study of congenital heart disease in 56,109 births

Mitchell, Shiela C.; Sellmann, Adolph H.; Westphal, Milton; Park, John

doi:10.1016/0002-9149(71)90053-1

Cited by 95 publications

(44 citation statements)

References 12 publications

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“…As stated above, trisomy-21 was the most common single etiological factor, having been detected in 10% of our patients. This level of prevalence is appreciably higher than the mean rate of about 5% reported from other countries [2,4,[17][18][19] and appears to be attributable to the relatively advanced age of the mothers of the affected children. The excess of trisomy-21 in turn explains the slightly higher prevalence of atrioventricular canal defect, there being a close association between the two conditions [12].…”

Section: Discussioncontrasting

confidence: 59%

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Pattern of Congenital Heart Disease in King Fahd Specialist Hospital, Buraidah

Jaiyesimi¹,

Ruberu²,

Misra

1993

Ann Saudi Med

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Section: Discussioncontrasting

confidence: 59%

“…In this present study, as in several others [4,5,15,17], no etiological factors were ascertainable in the majority of patients. Nonetheless, the role of chromosomal defects was noticeable.…”

Section: Discussioncontrasting

confidence: 40%

Pattern of Congenital Heart Disease in King Fahd Specialist Hospital, Buraidah

Jaiyesimi¹,

Ruberu²,

Misra

1993

Ann Saudi Med

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“…In other countries, Down syndrome accounts for about 5% of all CHD. 8,9,[18][19][20] In our series, the corresponding figure is 10% and, as we indicated in our previous communication, 2 the excess seems to be attributable to advanced maternal age. This, then, is one area that deserves attention whenever prevention strategies are to be formulated.…”

Section: Discussionsupporting

confidence: 81%

Noncardiac Defects in Children With Congenital Heart Disease

Jaiyesimi

Ruberu

1994

Annals of Saudi Medicine

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During a 39-month period, we prospectively studied the noncardiac defects (NCD) in 320 Saudi children who presented to us with congenital heart disease (CHD). Ninety NCD were detected in 80 (25%) of the 320 patients. Recognized syndromes comprised 49 (54%) of the 90 NCD; Down syndrome alone accounted for 32 (65%) of the 49 syndromal defects. Next to syndromal defects were musculoskeletal (24.5%), neurological (9%) and gastrointestinal defects (8%). As expected, there was an association between Down syndrome and cardiac septal defects: 28 (87.5%) of the 32 patients with this syndrome had some form of septal defect, and 16 of the 17 cases of atrioventricular (AV) canal defect occurred in patients with trisomy-21. Overall, the NCD were considered to be moderately severe or severe in 67 (84%) of the 80 affected patients. Indeed, 48 (60%) of the 80 patients (or 15% of the original group of 320 patients) had varying degrees of mental retardation. The results of this study confirm the well-recognized association between trisomy-21 and cardiac malformation, and emphasize the need to search for such defects in any child with Down phenotype, and suggest that there is a relatively high incidence of serious NCD in children with congenital heart disease. Nationwide studies on birth defects are needed, and if they yield data similar to those from our present study, appropriate prevention strategies will have to be considered. Ann Saudi Med 1994; 14(3):183-186.

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“…A through clinical examination was carried out within first 72 hours of birth. Presence of congenital heart disease (CHD) was suspected on the basis of following findings defined by Mitchell et al 6 . These are: a) Presence of a cardiac murmur.…”

Section: Methodsmentioning

confidence: 99%

Incidence of Congenital Heart Disease among Hospital Live Birth in a Tertiary Hospital of Bangladesh

Fatema

Chowdhury

1970

Cardiovasc. j.

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Background: Incidence of congenital heart disease is 8-10/1000 live birth which is established by many studies carried out in many centers worldwide. In Bangladesh no incidence study was carried out so far. Newborn children presenting with various forms of congenital heart disease is a common problem now a days. Neonatologists and paediatricians are now more conscious about early detection and treatment of newborn with congenital heart diseases. Diagnostic facilities are also available in many places. So an individual incidence record from an ideal center of our country is a demand of the time which led carrying out this study. Methods: This prospective study was carried out in Combined Military Hospital (CMH) Dhaka over a period of three years (2004 – 2006). All five thousand six hundred and sixty eight live births weighing more than 500 gm and more than 28 weeks gestational period were subjected to a thorough clinical examination within 72 hours of birth. Those suspected to have any form of congenital heart disease (CHD) were followed up every 4-6 wks for a period of 12 months. Echocardiography with color Doppler was performed in all these newborn including those who reported late but were delivered in obstetrics department of Combined Military Hospital Dhaka. Result: One hundred forty two babies out of 5668 live birth had CHD, ie, 25/1000 live births. Incidence of CHD was higher in pre terms as compared to full term live birth. Some of the patients (18.30%) has other associated somatic anomalies among which Down’s syndrome was commonest (9.15%). Most common congenital heart lesions were Atrial Septal Defect (ASD-26%), Ventricular Septal Defect (VSD-16.9%), Patent Ductus Arteriosus (PDA-18%), Tetralogy of Fallot (TOF-14%), Pulmonary Stenosis (PS-7.75%) etc. Those who were found to have congenital heart disease were managed accordingly. Some patients had spontaneous closure of defects in first year follow up period. Conclusion: The incidence of Congenital Heart Disease (CHD) depends upon various factors like nature of the samples (all live birth or all birth) or on the spot examination by a Paediatric cardiologist. A hospital which has Obstetric, Neonatal and Paediatric cardiology unit can carried out this kind of study successfully. In this study screening of asymptomatic high risk neonates also contributes in early detection of many trivial lesions. Severe lesions were also detected by the paediatric cardiologist who usually expire before being referred from other hospitals and before being diagnosis is established. So a higher incidence rate is recorded in this study. Key words: Congenital heart disease; Echocardiography DOI: http://dx.doi.org/10.3329/cardio.v1i1.8199 Cardiovasc. j. 2008; 1(1) : 14-20

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Etiologic correlates in a study of congenital heart disease in 56,109 births

Cited by 95 publications

References 12 publications

Pattern of Congenital Heart Disease in King Fahd Specialist Hospital, Buraidah

Pattern of Congenital Heart Disease in King Fahd Specialist Hospital, Buraidah

Noncardiac Defects in Children With Congenital Heart Disease

Incidence of Congenital Heart Disease among Hospital Live Birth in a Tertiary Hospital of Bangladesh

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