Congenital Heart Disease in 56,109 Births Incidence and Natural History

Mitchell, Shiela C.; Korones, Sheldon B.; Berendes, Heinz W.

doi:10.1161/01.cir.43.3.323

Cited by 1,137 publications

(639 citation statements)

References 9 publications

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“…Malformation of ears and ocular hypertelorism were the most prevalent injuries. This rate is higher than another studies 15 , which, even in 1971, have described similar extracardiac malformations in approximately 25% of patients. We must be cautious in comparing our data with other data in literature.…”

Section: Discussioncontrasting

confidence: 55%

Cardiopatias congênitas em um serviço de referência: evolução clínica e doenças associadas

Huber¹,

Peres²,

Santos³

et al. 2010

Arq. Bras. Cardiol.

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Section: Discussioncontrasting

confidence: 55%

Cardiopatias congênitas em um serviço de referência: evolução clínica e doenças associadas

Huber¹,

Peres²,

Santos³

et al. 2010

Arq. Bras. Cardiol.

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“…Congenital heart defects (CHDs) are the most common congenital abnormalities, with a birth prevalence of 8-10 per 1000 [1][2][3]. They account for 30% of all congenital malformations and are responsible for a significant proportion of fetal and neonatal mortality [3].…”

Section: Introductionmentioning

confidence: 99%

Increased nuchal translucency and congenital heart defects in euploid fetuses

Orvos

Wayda

Kozinszky

et al. 2002

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To determine the utility of the first-trimester fetal nuchal translucency (NT) thickness in the prediction of fetal cardiac malformations. Design: Retrospective study. Setting: Department of Obstetrics and Gynecology and Medical Genetics, University of Szeged. Methods: The pre-and postnatal course and outcome, and the relationship between the first-trimester fetal NT thickness and fetal congenital heart defects (CHDs) in 4309 pregnancies ended up with birth or therapeutic abortion between January 1998 and June 2000 were registered. Prenatal care included first-and second-trimester fetal sonography at weeks 10-13 and 18-20, respectively. Results: 4251 births and 58 first-and second-trimester therapeutic abortions due to lethal congenital malformations or chromosomal abnormalities were recorded. Altogether 209 (4.9%) congenital malformations were detected, 39 (18.7%) of which were heart defects with normal karyotype. At birth, 151 congenital malformations were diagnosed, 34 of them were known prenatally. The prevalence of CHDs was 9 per 1000 pregnancies. The measurement of fetal NT thickness was available in 35 of the 39 fetuses with heart defects: it was !3 mm in 18 (51.4%) and <3 mm in 17 (48.6%). A sensitivity of 51.4% was found at a cutoff of 3 mm. Conclusions: An increased NT thickness in chromosomally normal fetuses was found to be highly associated with CHDs and identified in more than half of the affected cases. Furthermore, an increased NT of !3 mm can be regarded a selection criterion for early second-trimester targeted fetal echocardiography and for increased fetal and neonatal surveillance. #

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“…Congenital heart disease was defined as "a gross structural abnormality of the heart or intrathoracic great vessels 61 that is actually not potentially of functional significance [26]. We excluded functionless abnormalities of great 62 veins, but included congenital arrhythmias and cardiomyopathies.…”

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confidence: 99%