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A CMOS SPAD-based QVGA image sensor with 8µm pixel pitch and 26.8% fill factor is presented. The combination of analogue pixel electronics and scalable sharedwell SPAD devices facilitate high resolution, high fill-factor SPAD imaging arrays exhibiting photon shot noise limited statistics. The SPAD has 47CPS dark count rate at 1.5V excess bias (EB), 39.5% photon detection probability at 480nm and minimum 1.1ns dead time at 1V EB. Analogue single photon counting imaging is demonstrated with maximum 14.2mV/SPAD event sensitivity and 0.06e-minimum equivalent read noise. Binary Quanta Image Sensor (QIS) 16kFPS real-time oversampling is shown, verifying single photon QIS theory with 4.6x over-exposure latitude and 0.168e-read noise.

In this paper, we report results obtained with a time-of-flight ranging/scanning system based on time-correlated single-photon counting. This system uses a pulsed picosecond diode laser and detects the scattered signal from a non-cooperative target surface using a semiconductor single-photon detector. A demonstration system has been constructed and used to examine the depth resolution obtainable as a function of the integrated number of photon returns. The depth resolution has been examined for integrated photon returns varying by five orders of magnitude, both by obtaining experimental measurements and by computer simulation. Depth resolutions of approximately 3 mm were obtained for only ten returned photons. The effect of the background signal, originating either from temporally uncorrelated light signals or from detector noise, has also been examined.

Abstract-This paper describes the design, fabrication, and performance of planar-geometry InGaAs-InP devices which were specifically developed for single-photon detection at a wavelength of 1550 nm. General performance issues such as dark count rate, single-photon detection efficiency, afterpulsing, and jitter are described.

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SummaryTo understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12–92 years before transplants and in 11 biopsies after transplants with high donor–recipient age‐mismatch. We also assessed liver function in 36 age‐mismatched recipients. The major findings were the following: (i) miR‐31‐5p, miR‐141‐3p, and miR‐200c‐3p increased with age, as assessed by microRNAs (miRs) and mRNA transcript profiling in 12 biopsies and results were validated by RT–qPCR in a total of 58 biopsies; (ii) telomere length measured by qPCR in 45 samples showed a significant age‐dependent shortage; (iii) a bioinformatic approach combining transcriptome and miRs data identified putative miRs targets, the most informative being GLT1, a glutamate transporter expressed in hepatocytes. GLT1 was demonstrated by luciferase assay to be a target of miR‐31‐5p and miR‐200c‐3p, and both its mRNA (RT–qPCR) and protein (immunohistochemistry) significantly decreased with age in liver biopsies and in hepatic centrilobular zone, respectively; (iv) miR‐31‐5p, miR‐141‐3p and miR‐200c‐3p expression was significantly affected by recipient age (older environment) as assessed in eleven cases of donor–recipient extreme age‐mismatch; (v) the analysis of recipients plasma by N‐glycans profiling, capable of assessing liver functions and biological age, showed that liver function recovered after transplants, independently of age‐mismatch, and recipients apparently ‘rejuvenated’ according to their glycomic age. In conclusion, we identified new markers of aging in human liver, their relevance in donor–recipient age‐mismatches in transplantation, and offered positive evidence for the use of organs from old donors.

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