The effect of aqueous extract of garlic (AEG) on triton WR 1339 induced hypercholesterolemia and hypertriglyceridemia has been studied in rats. A single injection of triton WR 1339 produced a significant increase in serum cholesterol and triglyceride (p < 0.001). The weight and total lipid of the livers of the triton treated rats were significantly increased (p < 0.001). AEG was extracted from chopped garlic pieces on which previously an exhaustive extraction had been made with petroleum ether, ethyl acetate and ethyl alcohol until no odour remained in them. The AEG so prepared had a significant effect on lowering the triton induced cholesterol (p < 0.001) and triglyceride (p < 0.001) in the blood. AEG showed a significant hypocholesterolemic and hypotriglyceridemic effect. These activities were higher than the reference compound nicotinamide, a well known hypocholesterolemic and hypotriglyceridemic molecule. Studies on the liver treated with AEG showed that the weight remained unperturbed but triglyceride was significantly lowered. However, some possible lipid content disturbances in the liver were suggested on the basis of data from the treated livers. It is therefore, inferred that AEG may contains hypocholesterolemic and hypotriglyceridemic components other than that already known. It is encouraging that the non-odorous character of AEG containing specific ingredient has a potential for use in lowering blood lipids.
Although, lipid lowering drugs regulate the blood serum lipids, they have several reported side effects. Therefore, a substance that is less toxic and yet effective would be beneficial. Here, we compared the antihypercholesterolemic effects of combinations of homeopathic mother tincture (HMT) Allium sativa Q (garlic) and Curcuma longa Q (turmeric), with standard lipid lowering drug statin. For experimentation, a total of 20 rabbits were recruited and divided into four groups with five rabbits (n = 5). Normal saline (NS) group served as control; second group served as high fat diet (HFD) group, third group received Allium sativa Q (garlic) and Curcuma longa Q (turmeric) and HFD (T and G group) while the fourth group received statin and HFD (statin group). At the end of the 8th week, blood was collected to analyze the comparative efficacy of Allium sativa Q, Curcuma longa Q and statin on total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride (TG). Various parameters measured (mg/dl) in HFD rabbits were, TC (291.76±2.2), LDL (244.20±8.3) and triglycerides (243.79±4.3) increased significantly and HDL (32.19±3.3) was reduced to an alarming level as compared to the NS group after eight weeks. TC, LDL and triglycerides level reduced significantly in Tand G group while the HDL level increased significantly as compared to HFD. In statin group, TC (148.37±1.2), LDL (76.32 ±3.4) and TG (104.33 ±8.9) decreased while HDL increased (p LESS than 0.05) as compared to the HFD after eight weeks. It was therefore concluded that that homeopathic medicine Allium sativa Q and Curcuma longa Q is equally good like statin and can safely be used to regulate the circulating serum lipid profile
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