Effect of aqueous extract of garlic on WR 1339 induced hyperlipidemia in rats

Abstract

The effect of aqueous extract of garlic (AEG) on triton WR 1339 induced hypercholesterolemia and hypertriglyceridemia has been studied in rats. A single injection of triton WR 1339 produced a significant increase in serum cholesterol and triglyceride (p < 0.001). The weight and total lipid of the livers of the triton treated rats were significantly increased (p < 0.001). AEG was extracted from chopped garlic pieces on which previously an exhaustive extraction had been made with petroleum ether, ethyl acetate and ethyl alcohol until no odour remained in them. The AEG so prepared had a significant effect on lowering the triton induced cholesterol (p < 0.001) and triglyceride (p < 0.001) in the blood. AEG showed a significant hypocholesterolemic and hypotriglyceridemic effect. These activities were higher than the reference compound nicotinamide, a well known hypocholesterolemic and hypotriglyceridemic molecule. Studies on the liver treated with AEG showed that the weight remained unperturbed but triglyceride was significantly lowered. However, some possible lipid content disturbances in the liver were suggested on the basis of data from the treated livers. It is therefore, inferred that AEG may contains hypocholesterolemic and hypotriglyceridemic components other than that already known. It is encouraging that the non-odorous character of AEG containing specific ingredient has a potential for use in lowering blood lipids.

Allium sativum

“…Durak et al ( 2002 ) demonstrated that cholesterol supplementation in rabbits led to dense plaque formation in the aortas of the rabbits, while garlic extract supplementation ameliorated blood lipid profi le increased antioxidant potential and could signifi cantly reduce plaque surface area in the aorta. Aqueous garlic extract exerted a signifi cant effect on lowering the Triton WR-1339-induced cholesterol and triglyceride in the rat's blood (Sarwar et al 2005 ). The hypocholesterolaemic and hypotriglyceridaemic effect of garlic extract was higher than the reference compound nicotinamide, a well-known hypocholesterolaemic and hypotriglyceridaemic compound.…”