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The effect of aqueous extract of garlic (AEG) on triton WR 1339 induced hypercholesterolemia and hypertriglyceridemia has been studied in rats. A single injection of triton WR 1339 produced a significant increase in serum cholesterol and triglyceride (p < 0.001). The weight and total lipid of the livers of the triton treated rats were significantly increased (p < 0.001). AEG was extracted from chopped garlic pieces on which previously an exhaustive extraction had been made with petroleum ether, ethyl acetate and ethyl alcohol until no odour remained in them. The AEG so prepared had a significant effect on lowering the triton induced cholesterol (p < 0.001) and triglyceride (p < 0.001) in the blood. AEG showed a significant hypocholesterolemic and hypotriglyceridemic effect. These activities were higher than the reference compound nicotinamide, a well known hypocholesterolemic and hypotriglyceridemic molecule. Studies on the liver treated with AEG showed that the weight remained unperturbed but triglyceride was significantly lowered. However, some possible lipid content disturbances in the liver were suggested on the basis of data from the treated livers. It is therefore, inferred that AEG may contains hypocholesterolemic and hypotriglyceridemic components other than that already known. It is encouraging that the non-odorous character of AEG containing specific ingredient has a potential for use in lowering blood lipids.

Back ground:Evidences suggest that oxidative stress may play an important role in the etiology of diabetes and diabetic complications. The free radicals can be encountered by the conventional treatment of diabetes. Alternatively, some plants and trace elements may be proven to bring desirable results including Coriander and Vanadyl sulfate. To produce hypoglycemic and anti oxidative effects, expensive and huge amount of these are required.Objective: An innovative method should be developed in which the Vanadyl sulfate may be up taken by coriander so that it must render it non toxic to produce hypoglycemic and anti oxidative effects in diabetic rats. Material & methods:150 albino rats were employed. 25 rats were kept normal (Group A). 125 made diabetic by STZ injection. Total 05 groups were identified and developed; each comprised of 25 rats. These were treated by Vanadyl sulfate (Group B), coriander only (Group C), Vanadyl sulfate up taken by coriander (V+C) (Group D), insulin treated (Group E) and last one did not receive any treatment (Group F). Results:The hypoglycemic effects and total antioxidant activity produced by the Vanadyl sulfate uptaken coriander are compatible than that of the insulin with negligible difference. All the other employed groups in the study did not reveal marked hypoglycemic activity. Pharmacological studies of Vanadyl sulfate uptaken herb demonstrated no deleterious effects. Conclusion:The detoxification of vanadyl sulfate has been achieved through possible auto oxidation of this valuable trace element by coriander. Vanadyl sulfate uptaken by coriander acts as antidiabetic agent and shows a considerable insulinomimetic and total antioxidant activity in the Diabetic rats.

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