Effects of customary drugs and modified herbal therapy on blood glucose and total antioxidant capacity in Streptozotocin induced diabetes in albino rats: A comparative analysis

Abstract

Back ground:Evidences suggest that oxidative stress may play an important role in the etiology of diabetes and diabetic complications. The free radicals can be encountered by the conventional treatment of diabetes. Alternatively, some plants and trace elements may be proven to bring desirable results including Coriander and Vanadyl sulfate. To produce hypoglycemic and anti oxidative effects, expensive and huge amount of these are required.Objective: An innovative method should be developed in which the Vanadyl sulfate may be up taken by coriander so that it must render it non toxic to produce hypoglycemic and anti oxidative effects in diabetic rats. Material & methods:150 albino rats were employed. 25 rats were kept normal (Group A). 125 made diabetic by STZ injection. Total 05 groups were identified and developed; each comprised of 25 rats. These were treated by Vanadyl sulfate (Group B), coriander only (Group C), Vanadyl sulfate up taken by coriander (V+C) (Group D), insulin treated (Group E) and last one did not receive any treatment (Group F). Results:The hypoglycemic effects and total antioxidant activity produced by the Vanadyl sulfate uptaken coriander are compatible than that of the insulin with negligible difference. All the other employed groups in the study did not reveal marked hypoglycemic activity. Pharmacological studies of Vanadyl sulfate uptaken herb demonstrated no deleterious effects. Conclusion:The detoxification of vanadyl sulfate has been achieved through possible auto oxidation of this valuable trace element by coriander. Vanadyl sulfate uptaken by coriander acts as antidiabetic agent and shows a considerable insulinomimetic and total antioxidant activity in the Diabetic rats.